Results 81 to 90 of about 118,468,089 (143)

Study of the intestinal permeability of levofloxacin in coperfusion in rats

, 2021
Levofloxacin (Levo) is a drug with an oral bioavailability near 100 % . According to the Biopharmaceutics Classification System it belongs to the class of high permeability.
López Yerena, Anallely, Garcia Sala, Xavier, Serrano Nieto, Álvaro, Escribano Ferrer, Elvira   +3 more
core  

A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied

International Journal of Nanomedicine, 2020
Jing-Yi Ye,1 Zhong-Yun Chen,1 Chuan-Li Huang,1 Bei Huang,2 Yu-Rong Zheng,2 Ying-Feng Zhang,1 Ban-Yi Lu,2 Lin He,2 Chang-Shun Liu3 ,* Xiao-Ying Long1,4, * 1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People’s Republic ...
Ye JY, Chen ZY, Huang CL, Huang B, Zheng YR, Zhang YF, Lu BY, He L, Liu CS, Long XY   +9 more
doaj  

Intelligent Continuum Micromachines in Complex Confined Spaces

SmartBot, EarlyView.
The cover depicts a conceptual design for an intelligent continuum micromachine entering a target capsule used in fusion‐energy research through its slender gas‐fill tube. By combining route‐adaptive deformation, embedded sensing, and a functional end effector, the robot could inspect hidden defects, assess local conditions, and support localized ...
Huayang Sai, Yunyue Yang, Shuxing Xu, Jinbo Hu, Jiliang Wang, Zhehao Gan, Wei Tang, Tian‐Yun Huang   +7 more
wiley   +1 more source

Transport of phenobarbitone into the intestinal lumen and the biliary tract following i.v. administration to rats

, 1986
The exsorption of intravenously administered phenobarbitone into the lumen of the small intestine of rats has been examined by an in-situ single-pass perfusion technique. The levels of the drug in the bile were about twice that in serum. Moreover, it was
Masahiro Nakano, Kazuhiko Arimori
core   +1 more source

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

Small, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou, Rujie Sun, Yuyang Zuo, David J. Peeler, Jonathan Yeow, Ruoxiao Xie, Junliang Lin, Yiming Ma, Yue Shao, Yuanxiong Cao, Zhengkun Chen, Molly M. Stevens   +11 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

, 2019
The rat single-pass intestinal perfusion (SPIP) model is commonly used to investigate gastrointestinal physiology and membrane drug transport. The SPIP model can be used with the intestinal segment inside or outside the abdomen.
Sjögren, Erik,, Tannergren, C.,, Sjöblom, Markus,, Lennernäs, Hans,, Peters, Karsten,, Lundqvist, A.,, Roos, Carl,, Dahlgren, David,   +7 more
core   +1 more source

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Drug Design, Development and Therapy, 2015
Jin-Yang Shen,1,* Xiao-Lin Yang,2,* Zhong-Lin Yang,1 Jun-Ping Kou,1 Fei Li11State Key Laboratory of Natural Medicines, China Pharmaceutical University, 2Key Laboratory of Pharmaceutical and Biological Marine Resources Research and Development of Jiangsu ...
Shen JY, Yang XL, Yang ZL, Kou JP, Li F
doaj  

Pulmonary Embolism—A Century of Progress

ANZ Journal of Surgery, EarlyView.
Reviews a century of progress in the diagnosis, prevention, and management of pulmonary embolism; from the first successful surgical embolectomy in 1924 to advanced imaging, pharmacological thromboprophylaxis, and treatment. In the 21st century, advances include catheter‐directed thrombolysis or mechanical thrombectomy under decision‐making guidance of
D. A. Watters
wiley   +1 more source

Rat intestinal drug permeability : A status report and summary of repeated determinations

, 2019
Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and development, and regulatory assessment. In situ rat models are often used to predict the corresponding human intestinal permeability data.
Sjögren, Erik,, Lennernäs, Hans,, Dubbelboer, Ilse R,, Dahlgren, David,   +3 more
core   +1 more source