Results 101 to 110 of about 118,468,089 (143)

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

High‐throughput, high‐fidelity reconstruction of whole mouse‐heart cytoarchitecture at cellular scale

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Experimental workflow of the dual‐camera light‐sheet microscope (dual‐mesoSPIM) pipeline. Intact adult mouse hearts undergo CUBIC‐based delipidation and refractive‐index matching, rendering the whole organ optically transparent (left).
Francesco Giardini   +12 more
wiley   +1 more source

Comparative Evaluation of HPLC and Capillary Electrophoresis in Intestinal Permeability of Oseltamivir Phosphate via Single-pass Intestinal Perfusion (SPIP) Method

open access: yes
<p>Introduction: Oseltamivir phosphate (OP), a widely used antiviral prodrug for influenza, requires accurate Biopharmaceutics Classification System (BCS) classification to inform formulation and bioequivalence decisions.
Halay, Gulpembe   +8 more
core   +1 more source

Sources, Transmission, and Control of Salmonella in Vertically Integrated Broiler Chicken Production: Farm, Hatchery, and Processing Plant

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT Salmonella remains one of the most important foodborne pathogens associated with poultry products, despite substantial progress in processing hygiene and antimicrobial interventions. This review critically examines the sources, transmission routes, and control strategies for Salmonella in vertically integrated broiler production systems ...
Deepak Subedi   +6 more
wiley   +1 more source

FAM3A Inhibits Plasma Triglyceride Levels via Microvasculature‐Involved Enhancement of VLDL‐Triglyceride Hydrolysis and Lipid Uptake

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
FAM3A enhances the PPARα signaling, leading to upregulated expression of lipid transporters including CD36 and TCF15. The upregulated CD36 and TCF15 enhance FA uptake and trans‐endothelial delivery in MVECs. Meanwhile, FAM3A‐enhanced PPARα signaling also increases LPL expression in myocytes and LPL position in lumen side of microvasculature to promote ...
Xiaohong Song   +7 more
wiley   +1 more source

Effect of ethanol on amino acid absorption across in vivo rat intestine

open access: yes, 1981
The acute effect of ethanol on amino acid absorption across the in vivo rat intestine was studied using single-pass continuous perfusion and recirculation techniques.
J. J. Hajjar   +3 more
core   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 39, 23 October 2026.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu   +7 more
wiley   +1 more source

Design and development of microemulsion drug delivery system of atorvastatin and study its intestinal permeability in rats [PDF]

open access: yes, 2011
The objective of this study was to design and develop microemulsion drug delivery system of Atorvastatin and to investigate its intestinal transport behavior using the single-pass intestinal perfusion method in rat.
Sawant, Krutika K.; Department of Pharmaceutics TIFACORE, MSU, Donors Plaza, Opp. University Main Office, The M. S. University of Baroda, Vadodara, Gujarat 390 002, India.   +2 more
core  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

open access: yesAdvanced Science, Volume 13, Issue 57, 14 October 2026.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez   +16 more
wiley   +1 more source

Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling

open access: yes, 2010
The present study explored the feasibility of a differential setup for the in situ perfusion technique with mesenteric cannulation in rats to assess drug interactions at the level of intestinal absorption.
Raf Mols   +7 more
core   +1 more source

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