Results 61 to 70 of about 114,728,006 (313)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Archeologische begeleiding plangebied Poeldonk te Den Dungen, Gemeente Sint-Michielsgestel

, 2021
In 2018 en 2019 heeft Ex-Situ Archeologie een archeologische begeleiding uitgevoerd volgens het protocol proefsleuven en/of opgraving in het plangebied Poeldonk te Den Dungen in de gemeente Sint- Michielsgestel.
Hoegen, drs R.D. (Ex-Situ Archeologie B.V.)
core   +1 more source

Stress State Change Monitoring Using Displacement Change Measurements [PDF]

, 2016
A method to back calculate stress state change was developed in Dynamic Control of Underground Mining Operations (DynaMine) research project. The purpose of this method is to provide real-time estimates of the stress state change caused by excavation. In
Uotinen, Lauri, Ritala, Frans, Siren, Topias   +2 more
core   +1 more source

Research on the correction method of hydraulic fracturing in-situ stress testing based on MLP-KFold [PDF]

Geoscientific Instrumentation, Methods and Data Systems
Hydraulic fracturing serves as a critical in-situ stress testing technique, where the accurate determination of rock fracture pressure and closure pressure in fracturing intervals is essential for precise in-situ stress estimation.
Y. Liu, J. Zhou, H. Chen, J. Luo, J. Luo
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Measurements Of In Situ Stress And Mining-Induced Stress In Beiminghe Iron Mine Of China

, 2009
In order to obtain the distribution rules of in situ stress and mining-induced stress of Beiminghe Iron Mine, the stress relief method by overcoring was used to measure the in situ stress, and the MC type bore-hole stress gauge was adopted to measure the
Xu WC, Li CH, Li HJ, Ouyang ZH, 欧阳振华   +4 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Exploration and application of in-situ stress estimation method based on core disking phenomenon of boreholes

Dizhi lixue xuebao
Objective  Rock core disking is a typical phenomenon that occurs in environments with high in-situ stress. The geometric characteristics and section shape of rock disking are related to the state of in-situ stress, and the site where this phenomenon ...
YAN Shaokun, WANG Chenghu, GAO Guiyun, LIU Jikun, DAI Xiangqian   +4 more
doaj   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Evaluating the Core-Based Stress Measurement in Mining Engineering—A Critical Review of the Diametrical Core Deformation Technique

Applied Sciences
Accurate determination of in situ stress is fundamental for the safe and efficient design of underground construction projects such as tunnels, caverns, and deep mining excavations. Conventional techniques—particularly overcoring and hydraulic fracturing—
Yizhuo Li, Baokun Zhou, Hani S. Mitri, Anlin Shao   +3 more
doaj   +1 more source