Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs [PDF]
BMC Veterinary Research, 2023 The objective of this study was to synthesize and characterize pharmaceutical characteristics of florfenicol sustained-release granules (FSRGs) in vitro and in vivo. FSRGs were synthesized using monostearate, polyethylene glycol 4000 and starch. In vitro
Wei-cong Yang +6 more
doaj +2 more sources
Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation. [PDF]
Nanomaterials (Basel), 2022 Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment.
Dubaj T +12 more
europepmc +12 more sources
Developing In Vitro–In Vivo Correlation for Bicalutamide Immediate-Release Dosage Forms with the Biphasic In Vitro Dissolution Test [PDF]
PharmaceuticsBackground/Objectives: Reflecting the interaction between dissolution and absorption, the biphasic dissolution system is an appealing approach for estimating the intestinal absorption of drugs in humans.
Nihal Tugce Ozaksun, Tuba Incecayir
doaj +2 more sources
In Vitro-In Vivo Correlation in Dermal Delivery: The Role of Excipients. [PDF]
Pharmaceutics, 2021 The composition of topical and transdermal formulations is known to determine the rate and the extent of drug delivery to and through the skin. However, to date, the role of excipients in these formulations on skin delivery of actives has received little attention from scientists in the field.
Patel A +4 more
europepmc +6 more sources
In Vitro–In Vivo Correlation of Tianeptine Sodium Sustained-Release Dual-Layer Tablets [PDF]
Molecules, 2022 Tianeptine tablets are currently marketed to be designed for immediate-release tablets. The tianeptine has a short half-life, making it difficult to design for sustained-release tablets and achieve bioequivalence with the tianeptine immediate-release ...
Ye-Ji Lee, Joo-Eun Kim
doaj +2 more sources
In vitro–in vivo correlation: Perspectives on model development [PDF]
International Journal of Pharmaceutics, 2011 In vitro-in vivo correlation (IVIVC) allows prediction of the in vivo performance of a drug based on the in vitro drug release profiles. To develop an effective IVIVC, the physicochemical and biopharmaceutical properties of the drug as well as the physiological environment in the body must be taken into consideration.
Kinam Park
exaly +3 more sources
Improving In Vitro–In Vivo Correlation (IVIVC) for Lipid-Based Formulations: Overcoming Challenges and Exploring Opportunities [PDF]
PharmaceuticsLipid-based formulations (LBFs) play a crucial role in enhancing the oral bioavailability of poorly water-soluble drugs by leveraging lipid digestion and solubilization processes. However, developing robust in vitro–in vivo correlations (IVIVCs) for LBFs
Arnaud Bourderi-Cambon +7 more
doaj +2 more sources
Franz Cell Diffusion Testing and Quantitative Confocal Raman Spectroscopy: In Vitro-In Vivo Correlation [PDF]
Pharmaceutics, 2020 Previously, we reported the use of Confocal Raman Spectroscopy (CRS) to investigate the topical delivery of actives and excipients. We have also correlated the results from CRS with findings from in vitro diffusion studies in human skin.
Fotis Iliopoulos +3 more
doaj +2 more sources
In Vitro-In Vivo Correlation (IVIVC) Population Modeling for the In Silico Bioequivalence of a Long-Acting Release Formulation of Progesterone. [PDF]
Pharmaceutics, 2021 Tosca EM +7 more
europepmc +2 more sources
Research on prescribing cascades: a scoping review
Frontiers in Pharmacology, 2023 Background: The concept of prescribing cascades has been proposed for more than 20 years, but the research progress and cognitive level varied in different countries.
Zhe Chen +22 more
doaj +1 more source