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In Vitro–in Vivo Correlation of Mucoadhesion Studies on Buccal Mucosa
Molecular Pharmaceutics, 2019For the development of novel buccoadhesive formulations, their physicochemical properties, strength of the interfacial joint, and residence time on the buccal mucosa are considered as a measure for their in vivo mucoadhesive properties. Focusing on these parameters, the predictive power of established in vitro systems was assessed for mucoadhesive ...
Randi Angela Baus +4 more
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In Vitro-ln Vivo Correlation for Modified-Release Formulations
Journal of Pharmaceutical Sciences, 1993A correlation of in vitro dissolution rate measurements with in vivo pharmacokinetic results in a human study was obtained for a sustained-release formulation of bromocriptine. Different methods were applied to reach this correlation, and the various outcomes were compared.
Drewe J, Guitard P
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Drug Metabolism in Man: in vivo and in vitro Correlations
1978In man the liver drug metabolizing ability may be determined by assaying drug kinetics after its administration or by measuring activity of drug metabolizing enzymes from liver biopsies. Little is known about the relationship between these parameters.
E A, Sotaniemi +4 more
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In Vitro-in Vivo Correlations — Quo Vadis
Drug Information Journal, 1995During the last 25 years, there has been considerable interest in in vitro-in vivo relationships of oral dosage forms. The advantages are obvious in terms of cost, time, and safety. This paper considers the problems involved in establishing in vitro-in vivo relationships, the dimensions of the task, and the different perspectives that apply to in vitro-
P. G. Welling +3 more
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In vitro-in vivo correlation of pharmaceutical aerosols
Advanced Drug Delivery Reviews, 2021Anthony J, Hickey, Philip Chi Lip, Kwok
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Perspectives of in vitro dissolution tests in establishing in vivo/in vitro correlations
European Journal of Drug Metabolism and Pharmacokinetics, 1993Perspectives of in vitro dissolution tests in establishing an in vivo/in vitro correlation are considered at three different levels. The first involves the selection of a drug product, or suitable batch(es), for the correlation study. This requires evaluation of the biopharmaceutical properties of the proposed drug from a profile compiled from a set of
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In Vitro Dissolution and In Vitro-In Vivo Correlation
The integration of computational systems in dissolution testing and in vitro-in vivo correlation (IVIVC) has revolutionized pharmaceutical development and quality control processes. Advanced software platforms enable automated data collection, analysis, and interpretation of dissolution profiles while facilitating real-time monitoring of drug release ...openaire +1 more source
Drug Information Journal, 1995
In vitro/in vivo correlations can and should be developed in many cases. This paper provides one approach to developing in vitro/in vivo correlations, along with examples, based upon the position of the United States Pharmacopeia (USP) Subcommittee on Bioavailability, Bioequivalence, and Dissolution (DBA).
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In vitro/in vivo correlations can and should be developed in many cases. This paper provides one approach to developing in vitro/in vivo correlations, along with examples, based upon the position of the United States Pharmacopeia (USP) Subcommittee on Bioavailability, Bioequivalence, and Dissolution (DBA).
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Issues Important to in Vitro-in Vivo Correlation
1997Although this book addresses numerous topics in the area of in vitro-in vivo correlation (IVIVC), this chapter summarizes some of the scientific and regulatory issues important to IVIVC and the Draft FDA Guidelines on IVIVC. This chapter was based on the open discussion sessions at the IVIVR Workshop in Baltimore, Maryland on September 4–6, 1996.
David Young +2 more
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