Results 81 to 90 of about 568,096 (301)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Comparative in vitro-in vivo correlation analysis with pioglitazone tablets

, 2022
Objective: To assess the in vitro. in vivo correlation of immediate release formulation of pioglitazone 30 mg film coated tablet. Methods: In vitro release data were obtained for test and reference formulation using the USP paddle method (Apparatus 2) at
Sajal Kumar Saha (13092990), A K A Chowdhury (13362834), S C Das (13362822), S C Bachar (13362801), M A Uddin (13362831), R H Kuddus (13362837)   +5 more
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Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging [PDF]

, 2017
Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer´s disease.
Windhorst, Albert D., van Waarde, Aren, Gert Luurtsema, Renske M. Raaphorst, Windhorst, A.D., Savolainen, H., Cantore, M., Albert Windhorst, Steeg, E. van de, Heli Savolainen, van de Steeg, Evita, Lammertsma, Adriaan A., Albert D. Windhorst, Cantore, Mariangela, Nicola A. Colabufo, Luurtsema, Geert, Elsinga, P.H., Raaphorst, R.M., Colabufo, N.A., Savolainen, Heli, Colabufo, Nicola A., Renske Raaphorst, Evita van de Steeg, Philip H. Elsinga, Elsinga, Philip H., van Waarde, Aren; id_orcid, Lammertsma, A.A., Adriaan Lammertsma, Raaphorst, Renske M., Luurtsema, G., Nicola Colabufo, Adriaan A. Lammertsma, Waarde, A. van, Luurtsema, Gert, Philip Elsinga, Mariangela Cantore, Aren van Waarde   +36 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An overview of the alarming impediments encountered while establishing an apposite IVIVC of nanomedicines necessitated its regulatory approval

OpenNano
For the past three decades, the principle of nanotechnology has been widely employed to develop pharmaceuticals and bio-pharmaceuticals that are successful for many disease therapies.
Nandakumar Selvasudha, Joseph Pushpa Sweety, Gover Antoniraj M, Kandasamy Ruckmani   +3 more
doaj   +1 more source

Brain targeted delivery of paclitaxel using endogenous ligand

Asian Journal of Pharmaceutical Sciences, 2016
The objective of the present investigation was to formulate nanoparticles constructed using PLGA polymer for the effective targeted delivery to brain via nasal route.
Sanjeev R. Acharya, Padmanabha R.V. Reddy   +1 more
doaj   +1 more source

Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

Pharmaceutics, 2020
This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution.
Dong-Seok Lee, Dong Wook Kang, Go-Wun Choi, Han-Gon Choi, Hea-Young Cho   +4 more
doaj   +1 more source

Neuronal in vitro models for the estimation of acute systemic toxicity.

, 2009
The objective of the EU funded integrated project "ACuteTox" is to develop a strategy in which general cytotoxicity, together with organ-specific endpoints and biokinetic features, are taken into consideration in the in vitro prediction of oral acute ...
Honegger, P., Gustafsson, H., Pallas, M., Rimbau, V., Zurich, M.G., Suñol, C., Coecke, S., Forsby, A., Vericat, J.A., Camins, A., Kinsner-Ovaskainen, A., Bal-Price, A.K., Fabre, N., Rodríguez-Farré, E.   +13 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

, 2012
Michael F Wempe,1 Janet W Lightner,2 Bettina Miller,1 Timothy J Iwen,1 Peter J Rice,1 Shin Wakui,3 Naohiko Anzai,4 Promsuk Jutabha,4 Hitoshi Endou51Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Anschutz Medical
Wempe MF, Endou H, Jutabha P, Iwen TJ, Wakui S, Lightner JW, Rice PJ, Anzai N, Miller B   +8 more
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