Results 101 to 110 of about 568,096 (301)

Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy

, 2005
OBJECTIVE: To compare morphologic features of keratoconus as observed in vivo with a slit scanning confocal microscope and in vitro using light microscopy.
Bonshek, Richard E., Hollingsworth, Joanna G., Efron, Nathan   +2 more
core  

Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation

, 2010
Sanyuan Hu1, Yangde Zhang21Xiangya School of Medicine and 2National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha, Hunan Province, People’s Republic of ChinaAbstract: Endostar, a novel
null Hu, null Yangde Zhang, Yangde Zhang, Sanyuan Hu   +3 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Study on the non labeled synthetic colorants were detected in natural food pigments and condiment

Zhongguo shipin weisheng zazhi
ObjectiveThe method of high performance liquid chromatography （HPLC） was developed to study the detection of synthetic colorants in natural pigments and condiment.MethodsThe analytes were extracted by direct ultrasonic extraction with water. The analytes
WEI Yutao, WEN Quan, TANG Weiying, ZHONG Ciping, YU Xiaoqin, LI Shucai, XU Feng, SU Yan, TANG Ruiyi   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparisons of in vitro Fick’s first law, lipolysis, and in vivo rat models for oral absorption on BCS II drugs in SNEDDS

International Journal of Nanomedicine, 2019
Jingyi Ye,1,* Huiyi Wu,1,* Chuanli Huang,1 Wanting Lin,2 Caifeng Zhang,1 Bei Huang,2 Banyi Lu,2 Hongyu Xu,2 Xiaoling Li,3 Xiaoying Long1,41Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People&
Ye J, Wu H, Huang C, Lin W, Zhang C, Huang B, Lu B, Xu H, Li X, Long X   +9 more
doaj  

High-selective hepatic removel of deoxyschizandrin in microsomes in vitro and correlation with perfusion data

, 2010
Aim to develop deoxyschizandrin (DS), one of the major active lignans isolated from Schisandra fruits, as a novel high-selective in vivo CYP3A probe. We investigated the respective contributions of enzyme and transporter to hepatic clearance in vitro and
Ling Yang, 吴敬敬
core  

Alkylcyanoacrylate drug carriers: I. Physicochemical characterization of nanoparticles with different alkyl chain length [PDF]

, 1992
Alkylcyanoacrylate particles were physico-chemically characterized in terms of size, surface charge, zeta potential, interaction with charged serum components and surface hydrophobicity as relevant parameters influencing the in vitro interaction with ...
Müller, R. H., Blunk, Torsten, Herbort, J., Lherm, C., Couvreur, P.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs

Pharmaceutics
Background/Objectives. This research supports the development of long-acting injectables (LAIs) via in situ gel (ISG) technology by illustrating the influence of drug properties and formulation variables on in vitro drug release (Part 1), and providing ...
Sandy Van Hemelryck, Charlotte Vercammen, Eline Seldeslachts, Koen Wuyts, Ils Pijpers, René Holm, Erik Mannaert, Peter Langguth   +7 more
doaj   +1 more source