Results 121 to 130 of about 568,096 (301)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Development and In Vitro-In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease. [PDF]

Int J Mol Sci, 2023
Zhang C, Shao H, Han Z, Liu B, Feng J, Zhang J, Zhang W, Zhang K, Yang Q, Wu S.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Editorial: New mechanisms and drugs for the treatment of cardiovascular disease with diabetes

Frontiers in Cardiovascular Medicine, 2023
Shanshan Zhang, Shanshan Zhang, Shanshan Zhang, Jingwei Li, Yuli Huang, Jie Yu, Xiong-Fei Pan, Xiong-Fei Pan   +7 more
doaj   +1 more source

Antioxidents or reduced oxygen tension as a defense system in T cells ex vivo and in vitro

, 2009
Age-related deterioration and dysregulation of T cell function, termed ‘immunosenescence’, may lead to increased mortality and morbidity in humans through greater susceptibility to infections and disease.
Marthandan, SS, Marthandan, Shiva Shankar   +1 more
core  

Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology

, 2006
OBJECTIVES: The goal of the present study was to compare the accuracy of in vivo tissue characterization obtained by intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, known as Virtual Histology (VH), to the in vitro histopathology of ...
Terashima, Mitsuyasu, Matsubara, Tetsuo, Surmely, Jean-François, Ehara, Mariko, Virmani, Renu, Katoh, Osamu, Suzuki, Takahiko, Ito, Tatsuya, Tsuchikane, Etsuo, Vince, D Geoffrey, Nasu, Kenya, Vince, D. Geoffrey, Takeda, Yoshihiro, Murata, Akira   +13 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Differentiating intratumoral melanocytes from Langerhans cells in nonmelanocytic pigmented skin tumors in vivo by label-free third-harmonic generation microscopy

, 2017
Morphology and distribution of melanocytes are critical imaging information for the diagnosis of melanocytic lesions. However, how to image intratumoral melanocytes noninvasively in pigmented skin tumors is seldom investigated. Third-harmonic generation (
廖怡華, Weng, Wei-Hung;Liao, Yi-Hua;Tsai, Ming-Rung;Wei, Ming-Liang;Huang, Hsin-Yi;Sun, Chi-Kuang   +1 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source