Results 111 to 120 of about 568,096 (301)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Minimum Antibiotic Levels for Selecting a Resistance Plasmid in a Gnotobiotic Animal Model [PDF]
, 1989 The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree rates colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid.
Lumeau, Solange +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis
Studia Universitatis Babes-Bolyai ChemiaThis study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models.
Maria CODREANU +5 more
doaj +1 more source
, 2009 At present, toxicogenomics for predictive toxicology is mostly used in vivo in order to obtain comprehensive information about the involved mode and mechanism of action of toxicants.
Schug,M. +6 more
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In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption
, 2009 Oral administration is the most common route for drug administration. However, after oral administration, the absorption may be erratic and incomplete.
del Amo, Eva M. +2 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
International Journal of Nanomedicine, 2012 Xia Cao*, Wen-Wen Deng*, Min Fu*, Liang Wang, Shan-Shan Tong, Ya-Wei Wei, Ying Xu, Wei-Yan Su, Xi-Ming Xu, Jiang-Nan YuDepartment of Pharmaceutics, School of Pharmacy, and Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University ...
Cao X +8 more
doaj
Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines
Nano TransMedNanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles,
Ugochi E. Ewii +7 more
doaj +1 more source
Dosimetry for 6-[18F]Fluoro-L-DOPA in humans based on in vivo microPET scans and ex vivo tissue distribution in mice [PDF]
, 2012 Radiation dosimetry of new radiopharmaceuticals generally starts with studies in small animals such as mice and rats. The traditional technique has long been ex vivo measurement of the biodistribution over time using harvested organs at different times ...
Lemaire, Christian +8 more
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