Results 131 to 140 of about 568,096 (301)

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke, Petra Steinacker, Steffen Halbgebauer, Patrick Oeckl, Geert Mayer, Markus Otto   +5 more
wiley   +1 more source

Algorithms for characterizing brain metabolites in two-dimensional in vivo MR correlation spectroscopy

, 2011
Traditional analyses of in vivo 1D MR spectroscopy of brain metabolites have been limited to the inspection of one-dimensional free induction decay (FID) signals from which only a limited number of metabolites are clearly observable.
Mountford, C.E., C. Mountford, Keshava, Nirmal, Cocuzzo, D., Keshava, N., Ramadan, Saadallah, Lin, Alexander, Cocuzzo, Daniel, D. Cocuzzo, Mountford, Carolyn, N. Keshava, S. Ramadan, Lin, A., A. Lin, Ramadan, S.   +14 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model. [PDF]

Drug Deliv Transl Res, 2023
Pereira-da-Mota AF, Vivero-Lopez M, Garg P, Phan CM, Concheiro A, Jones L, Alvarez-Lorenzo C.   +6 more
europepmc   +1 more source

Telescopic crowns: extra-oral and intra-oral retention force measurement--in vitro/in vivo correlation

, 2011
This study deals with the determination of the retentive forces of telescopic crowns measured extra- and intra-orally and the correlation of these ...
Stark, Helmut, Ludger Keilig, Norbert Enkling, Dominik Kraus, Enkling, Norbert, Lina Gölz, Kraus, Dominik, Gölz, Lina, Anja Hansen, Stefan Bayer, Bayer, Stefan, Hansen, Anja, Helmut Stark, Keilig, Ludger   +13 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

In Vitro-In Vivo Correlation of Posaconazole-Amphotericin B Combination against Candida albicans: In Vitro Interacting Concentrations Are Associated with In Vivo Free Drug Levels. [PDF]

J Fungi (Basel), 2023
Meletiadis J, Beredaki MI, Elefanti A, Pournaras S, Muller A.   +4 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Establishment of Level a In Vitro-In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study. [PDF]

Pharmaceutics, 2022
Lee DY, Shin S, Kim TH, Shin BS.
europepmc   +1 more source

In vitro models for the blood-brain barrier

, 2005
The aim of the present study was to identify a model for the blood-brain barrier based on the use of a continuous cell line, and to investigate the specificity of this model.
Osterberg, T., Stanimirovic, D., Nilsson, J., Terasaki, T., Fenart, Laurence, Öberg, J.-O., Garberg, P., Mabondzo, Aloïse, M., Raub, T. J., Ball, M., Hurst, D. R., Oberg, J., Hurst, R., Raub, T., Cecchelli, Roméo, Fenart, L., Ball, Marguerite, Mabondzo, A., Stanimirovic, Danica, Nilsson, J. E., Borg, N., Cecchelli, R., Lindmark, T.   +22 more
core