Results 141 to 150 of about 568,096 (301)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine

, 2015
This work illustrates the use of Physiologically-Based Toxicokinetic (PBTK) modelling in in vitro-to-in vivo correlation (IVIVC) of kinetic measures of caffeine skin penetration and liver metabolism, as well as dose metrics of caffeine-induced HepaRG ...
SALA BENITO Jose', PAINI Alicia, BURTON Julien, URANI Chiara, GAJEWSKA Monika, BRIESEN Heiko, WORTH Andrew, SCHRAMM Karl-Werner   +7 more
core   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Formulation of Enalapril Maleate Nanoproniosomal Gels and Their Pharmacokinetic Evaluations in Hypertensive Albino Wistar Rats: Ex Vivo and In Vivo Approaches

Nano Biomedicine and Engineering
Proniosomes are drug-encapsulated, nanoscale vesicular structures that generate multilamellar niosomal dispersions upon hydration. This study aimed to develop enalapril maleate nanoproniosomal gels and assess their effectiveness in experimental ...
Mekala Sabareesh, Jayaraman Rajangam, Janapati Pedda Yanadaiah   +2 more
doaj   +1 more source

Natural Bone‐Derived Ceramic Scaffolds Functionalized with Chitosan‐Gold, Chitosan‐Magnesium, and Chitosan‐Zinc for Enhanced Antibacterial Activity

Advanced Engineering Materials, EarlyView.
This study reports the development of antibacterial ceramic scaffolds derived from natural bovine bone. The bones were processed through sequential boiling and hydrogen peroxide treatment to remove organic matter, producing porous, mineral‐rich scaffolds.
Mohamad Hassan Taherian, Anh Thi Le, Anh Thi Van Le, Dung My Thi Dang, Tin Chanh Duc Doan, Chien Mau Dang, Martin Bolduc   +6 more
wiley   +1 more source

IN VITRO AND IN VIVO DETERMINATION OF ANKLE JOINT AND SUBTALAR JOINT AXES USING THE HELICAL AXIS METHOD

, 2008
INTRODUCTION: In the kinematic analysis of most human joints continuous motion can be simulated by a sequence of finite motion steps of one part of the joint relative to the other part. In previous studies different experimental setups were used in vitro
Alt, Wilfried, Lohrer, Heinz, Rappe, Bernd, Jacob, H. A. C., Gollhofer, Albert   +4 more
core  

Correlation of Cidality under physiology of in-vitro vs. in-vivo.

, 2016
The low pH condition appears to be the ideal screening system (R = 0.9856) showing linearity during a correlation of different in-vitro screens of alternate stress responses versus the in-vivo outcome for selection of cidal inhibitors.
Nanduri Robert (2657527), Parvinder Kaur (235201), Anand Anbarasu (539441), Sudha Ramaiah (539442), Upneet K. Sokhi (470793), Radha Krishan Shandil (2657530), Supreeth Guptha (1734121), Shridhar Narayanan (456463), Santanu Datta (141626), Naveen Kumar (66313)   +9 more
core   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Biowaiver study of oral tabletted ethylcellulose microcapsules of a BCS class I drug

Bulletin of the Chemical Society of Ethiopia, 2009
This article describes the preparation and characterization (in vitro and in vivo) of three different sustained-release salbutamol sulfate−ethylcellulose tabletted microparticles (T1, T2 and T3) and reference sustained release tablet (Ventolin 8 mg
Ghulam Murtaza, Mahmood Ahmad, Naveed Akhtar   +2 more
doaj