Results 91 to 100 of about 8,658,473 (396)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Establishing endotoxin limits to enhance the reliability of in vitro immunogenicity risk assessments

mAbs
Immunogenic responses to biotherapeutics often lead to termination of their development because the resulting anti-drug-antibodies (ADA) can negatively impact pharmacology, safety, and efficacy.
Yun Hee Jeong, Gillian Lennon, Geertruida Veldman, Daniel M. Serna, Alexander Ibrahimov   +4 more
doaj   +1 more source

Hepatotoxicity of Pyrrolizidine Alkaloids

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: This article aimed 1) to review herbal medicine containing pyrrolizidine alkaloids (PA)-induced toxicities of the liver; 2) to encourage the recognition and prevention of common problems encountered when using complementary and alternative ...
Manuela G Neuman, Lawrence Cohen, Mihai Opris, Radu M Nanau, Hyunjin Jeong   +4 more
doaj   +1 more source

In Vitro Shoot Regeneration of Indonesian Bananas (Musa Spp.) CV. Ambon Kuning and Raja Bulu, Plantlet Acclimatizationand Field Performance [PDF]

, 2015
The aim of this study was to observe responses of two banana cultivars ‘Ambon' and ‘Raja Bulu' on different BA concentrations and effects of different media and fertilizer on survival and growth of plantlets.
Danial, E. (Ekawati), Hapsoro, D. (Dwi), Yusnita, Y. (Yusnita)   +2 more
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Pelestarian secara In Vitro melalui Metode Pertumbuhan Lambat pada Beberapa Genotipe Ubi Jalar (Ipomea Batatas (L) Lam) [PDF]

, 2013
The objectives of this research were to estimate responses of several sweet potato genotypes in preservation media through in vitro slow growth preservation, and to achieve cheap and accessible media.
Laisina, J. K. (Jean)
core  

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Perinatal Outcomes of Singleton, Twin and Triplet Gestations after Oocyte Donation: A Retrospective, Population-Based Cohort Analysis

Children
Background/Objectives: Although high live birth rates are associated with oocyte donation (OD), these pregnancies are associated with increased obstetric and perinatal risks.
Or Eliner, Roni Rahav Koren, Hila Shalev Ram, Mattan Levi, Einat Haikin Herzberger, Amir Wiser, Netanella Miller   +6 more
doaj   +1 more source

Teknik Pengujian in Vitro Ketahanan Pisang Terhadap Penyakit Layu Fusarium Menggunakan Filtrat Toksin Dari Kultur Fusarium Oxysporum F. SP. Cubense [PDF]

, 2005
Sejauh ini informasi mengenai uji ketahanan pisang terhadap patogen layu fusarium menggunakan filtrat toksin patogennya masih terbatas. Penelitian ini dilaksanakan pada bulan Juni 2002 sampai dengan Maret 2003 di laboratorium kultur jaringan ...
Handayani, H. (H), Jumjunidang, J. (Jumjunidang), Nasir, N. (Nasril), Riska, R. (Riska)   +3 more
core