Results 91 to 100 of about 5,914,882 (359)

Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties [PDF]

, 2020
Forooz Soroor, Moshe S. Kim, Oliva Palander, Yadu Balachandran, Richard F. Collins, Samir Benlekbir, John L. Rubinstein, William S. Trimble   +7 more
openalex   +1 more source

Flow-enhanced vascularization and maturation of kidney organoids in vitro

Nature Methods, 2018
Kidney organoids derived from human pluripotent stem cells have glomerular- and tubular-like compartments that are largely avascular and immature in static culture.
Kimberly A. Homan, Navin R Gupta, Katharina T. Kroll, David B. Kolesky, Mark A. Skylar-Scott, Tomoya Miyoshi, Donald Mau, M. T. Valerius, Thomas C. Ferrante, Joseph V. Bonventre, Jennifer A. Lewis, Ryuji Morizane   +11 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

Toxics
Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin   +3 more
doaj   +1 more source

Hepatotoxicity of Pyrrolizidine Alkaloids

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: This article aimed 1) to review herbal medicine containing pyrrolizidine alkaloids (PA)-induced toxicities of the liver; 2) to encourage the recognition and prevention of common problems encountered when using complementary and alternative ...
Manuela G Neuman, Lawrence Cohen, Mihai Opris, Radu M Nanau, Hyunjin Jeong   +4 more
doaj   +1 more source

Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility

Frontiers in Bioengineering and Biotechnology, 2018
Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO 10993-4 are required prior to clinical applications.
Marbod Weber, H. Steinle, S. Golombek, L. Hann, C. Schlensak, H. Wendel, M. Avci-Adali   +6 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Neural Stimulation In Vitro and In Vivo by Photoacoustic Nanotransducers [PDF]

, 2020
Ying Jiang, Yimin Huang, Xuyi Luo, Jiayingzi Wu, Haonan Zong, Linli Shi, Ran Cheng, Yifan Zhu, Shan Jiang, Lu Lan, Xiaoting Jia, Jianguo Mei, Heng‐Ye Man, Ji‐Xin Cheng, Chen Yang   +14 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source