Results 71 to 80 of about 120,681,618 (266)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

In Vitro Antibiotic Susceptibilities of Ocular Isolates in North and South America

, 1998
PURPOSETo assess the in vitro susceptibility of ocular bacterial isolates from North and South America to antiinfectives that are commonly used in the treatment of external ocular infection.
In Vitro Antibiotic Testing Grp, Jensen, Harold, Felix, Carlos   +2 more
core   +1 more source

Clinical Outcomes of ICSI Using Advanced Quantitative Phase Microscopy

Bioengineering
This study evaluated the clinical outcomes associated with quantitative phase microscopy (QPM), an advanced 3D morphological sperm analysis technique using a virtual, stained model developed in our facility that indicates whether the inspected sperm ...
Roni Rahav-Koren, Luba Nemerovsky, Yehudith Ghetler, Einat Haikin-Herzberger, Liat Salzer-Sheelo, Netanella Miller, Amir Wiser, Mattan Levi   +7 more
doaj   +1 more source

Diagnosing ventilator-associated pneumonia (VAP) in UK NHS ICUs: the perceived value and role of a novel optical technology

Diagnostic and Prognostic Research, 2022
Background Diagnosing ventilator-associated pneumonia (VAP) in an intensive care unit (ICU) is a complex process. Our aim was to collect, evaluate and represent the information relating to current clinical practice for the diagnosis of VAP in UK NHS ICUs,
W. S. Jones, J. Suklan, A. Winter, K. Green, T. Craven, A. Bruce, J. Mair, K. Dhaliwal, T. Walsh, A. J. Simpson, S. Graziadio, A. J. Allen   +11 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

In vitro micropropagation and ex vitro acclimation of Bupleurum kaoi - An endangered medicinal plant native to Taiwan [PDF]

, 2014
This study reports an improved protocol for in vitro-shoot multiplication and ex vitro acclimation of Bupleurum kaoi, an endangered medicinal herb. Nodal segments were cultured in half-strength Murashige and Skoog (MS) basal medium supplemented with ...
Tsay, H.S., Hsia, C.N., Yeh, M.S., Chen, U.C., Agrawal, D.C.   +4 more
core   +1 more source

The use of an in vitro cornea for predicting ocular toxicity

, 2022
S.309-318 : Ill., Lit.This paper presents the development of an in vitro cornea model to assess ocular irritancy. The in vitro cornea is an organotypic culture composed of corneal stromal fibroblasts embedded in a matrix of collagen with an underlying ...
Maier-Reif, K., Graeve, T., Schneider, A.I.   +2 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Oxygen tension affects histone remodeling of in vitro-produced embryos in a bovine model

, 2015
In vitro production of bovine embryos is a biotechnology of great economic impact. Epigenetic processes, such as histone remodeling, control gene expression and are essential for proper embryo development.
Gaspar, Roberta C., Garcia, Joaquim M., Vantini, Roberta [UNESP], Penteado, Joao C. T. [UNESP], Rocha, Carlos V. da, Correa, Carolina A. P., del Collado, Maite, Vantini, Roberta, Correa, Carolina A. P. [UNESP], del Collado, Maite [UNESP], Arnold, Daniel R., Lopes, Flavia L., Rocha, Carlos V. da [UNESP], Lopes, Flavia L. [UNESP], Penteado, Joao C. T., Gaspar, Roberta C. [UNESP], Garcia, Joaquim M. [UNESP]   +16 more
core   +1 more source

The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation

Toxics
Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also be induced by treating non-fibrotic hPCLS with a fibrotic cocktail (FC).
Méry Marimoutou, Vivek Patel, Jae Hun Kim, Niccole Schaible, Jose Alvarez, Joseph Hughes, McKenzie Obermok, Carlos Iván Rodríguez, Thomas Kallarakal, Béla Suki, Khalid Amin, Ramaswamy Krishnan, Holger Peter Behrsing   +12 more
doaj   +1 more source