Results 71 to 80 of about 5,663,004 (310)

Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells [PDF]

, 2014
In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient\u27s tumor and corresponding in vitro and in vivo models is important for understanding the potential clinical relevance of ...
Ahn, Susie, Baysan, Mehmet, Belova, Galina I., Bozdag, Serdar, Cam, Margaret C., Fine, Howard A., Kotliarova, Svetlana, Meltzer, Paul, Riddick, Gregory, Song, Hua, Stevenson, Holly, Walling, Jennifer, Woolard, Kevin, Zhang, Wei   +13 more
core   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Research Article [PDF]

published quarterly. The aim of IJPBS is to publish. peer reviewed research and review articles rapidly without delay in the developing field of pharmaceutical and biological ...
Cladophora Rupestris, In-vitro Bioactivity, Of Marine Seaweed   +2 more
core  

Rate-controlled rectal drug delivery in man with a hydrogel preparation [PDF]

, 1986
Cylindrical hydrogels of hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent were prepared by radical polymerization at 70°C.
Boer, A.G. de, Breimer, D.D., Feijen, J., Leede, L.G.J. de, Pörtzgen, E.   +4 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Reproductive Axis Recovery Post-Ovarian Stimulation and Gonadotropin-Releasing Hormone Agonist (GnRH-a) Trigger: Observational Case Series

Reproductive Medicine
Background: Following gonadotropin-releasing hormone (GnRH) agonist trigger and “freeze all” in order to prevent ovarian hyper-stimulation syndrome (OHSS), patients are usually anxious to continue immediately with a frozen embryo transfer (FET ...
Tatyana Breizman, Shahar Kol
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Induksi In Vitro Tanaman Gaharu (Aquilaria Microcarpa Baill.) dari Eksplan Tunas Aksilar dengan Penambahan 6-benzylaminopurine (Bap) [PDF]

, 2014
Aquilaria microcarpa Baill. can produce agarwood products that can be used for various purposes, therefore it can caus a high demand for the product. Nowadays, these species are being hunted in their natural habitats.
Lestari, W. (Wahyu), Novriyanti, E. (Eka), Wahyuni, S. R. (Suci)   +2 more
core  

In vitro mutagenesis of Cymbidium La bell “Anna Belle” by γ-rays irradiation and oligochitosan interaction [PDF]

, 2017
The optimum media for multiplication of protocorm like bodies (PLBs) and shoot buds of Cymbidium La bell “Anna Belle” were studied in order to prepare the in vitro samples for irradiation.
Luan, L. Q. (Le), Xo, D. H. (Duong)
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source