Results 61 to 70 of about 120,681,618 (266)
, 2016 The present study aimed to verify the effects of induced polyploidization on Pfaffia glomerata regarding its 20-hydroxyecdysone (20E) production both in vitro and under greenhouse conditions, its in vitro photoautotrophic potential, and its ex vitro ...
Otoni, Wagner Campos +9 more
core +1 more source
Journal of Clinical MicrobiologyThe absence of a World Health Organization (WHO) international standard for Chikungunya virus (CHIKV) nucleic acid testing has long impeded the comparability of diagnostic results across different assays and platforms.
Tingting Ma +5 more
doaj +1 more source
Identifying miR-431-5p as a promising candidate biomarker for early-onset severe preeclampsia through integrated bioinformatic and clinical analyses: a retrospective study [PDF]
PeerJBackground Early-onset severe preeclampsia (EOSPE) is a serious pregnancy complication associated with adverse maternal and neonatal outcomes. This study aimed to identify potential diagnostic biomarkers for EOSPE and to investigate their clinical ...
Jianxin Zhang +8 more
doaj +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2008 The main aim of the ACuteTox project, under EU 6th Framework programme, is to investigate whether animal toxicity tests for acute systemic toxicity could be replaced by a combination of alternative assays. Data for 97 reference chemicals was collected in
Clothier, Richard +3 more
core +1 more source
Safety of Anti-Tumor Necrosis Factor Therapies in Arthritis Patients
Journal of Pharmacy & Pharmaceutical Sciences, 2014 Purpose. Inflammatory and rheumatic arthritis remain leading causes of disability worldwide. The arthritis therapeutic area commands the largest market for the prescription of biological and non-steroidal anti-inflammatory drugs (NSAID).
Radu M Nanau, Manuela G Neuman
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Efficacy and Safety of Platelet Inhibitors
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Ischemic heart disease is the second leading cause of death in the world. The proportion of deaths resulting from this condition has decreased in the last two decades, mainly as a result of improved primary and secondary prevention of cardiovascular ...
Ornella Binazon +3 more
doaj +1 more source