Results 41 to 50 of about 5,663,004 (310)
Safety of Anti-Tumor Necrosis Factor Therapies in Arthritis Patients
Journal of Pharmacy & Pharmaceutical Sciences, 2014 Purpose. Inflammatory and rheumatic arthritis remain leading causes of disability worldwide. The arthritis therapeutic area commands the largest market for the prescription of biological and non-steroidal anti-inflammatory drugs (NSAID).
Radu M Nanau, Manuela G Neuman
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
iLABMEDMolecular point‐of‐care testing (POCT) is characterized by high sensitivity, low reagent demand, fast mixing speed, rapid turnaround time, and ease of use, making it appealing for diagnosing infectious diseases.
Shanshan Ren, Donglai Liu, Sihong Xu
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mAbs, 2021 Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging.
Pallavi Bhatta +12 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Scientific Reports, 2023 In order to identify biomarkers for earlier prediction of COVID-19 outcome, we collected blood samples from patients with fatal outcomes (non-survivors) and with positive clinical outcomes (survivors) at ICU admission and after seven days.
Simone Kattner +8 more
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From NAFLD to MAFLD: Aligning Translational In Vitro Research to Clinical Insights
Biomedicines, 2022 Although most same-stage non-alcoholic fatty liver disease (NAFLD) patients exhibit similar histologic sequelae, the underlying mechanisms appear to be highly heterogeneous.
Alexandra Gatzios +7 more
doaj +1 more source
Current Opinion in Cell Biology, 2021 Organoids are three-dimensional structures that self-organize from human pluripotent stem cells or primary tissue, potentially serving as a traceable and manipulatable platform to facilitate our understanding of organogenesis. Despite the ongoing advancement in generating organoids of diverse systems, biological applications of in vitro generated ...
Kentaro Iwasawa, Takanori Takebe
openaire +2 more sources
In Vitro Infectivity Study of Cryopreserved Irradiated Intraerythrocytic Form of Plasmodium Falciparum [PDF]
, 2017 In control human malaria infection studies using irradiated Plasmodium falciparum, the cell bank of irradiated P. falciparum infected erythrocytes is needed.
Darlina, D. (D) +6 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source