Results 111 to 120 of about 8,610,712 (380)

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Frontiers in Pharmacology, 2018
Drug development is a lengthy and costly process that proceeds through several stages from target identification to lead discovery and optimization, preclinical validation and clinical trials culminating in approval for clinical use. An important step in
Sigrid A. Langhans
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Comparação entre vitrificação e congelamento lento sobre o desenvolvimento pós-descongelamento de embriões bovinos produzidos in vitro

Semina: Ciências Agrárias
Avaliou-se o desenvolvimento pós-descongelamento de embriões bovinos produzidos in vitro (PIV) criopreservados pela técnica de vitrificação e de congelamento lento em diferentes dias após a fertilização in vitro (FIV). Foram realizadas 9 réplicas de PIV.
Vanessa Rachele Ribeiro Nunes, Jennifer Teodoro Ferreira Gregianini, Helton Aparecido Garcia Gregianini, Bárbara Souza Fantin, Bárbara Loureiro, Rafael Augusto Satrapa   +5 more
doaj   +1 more source

Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions

Biomolecules, 2015
Background: The quantitative, measurable detection of drinking is important for the successful treatment of alcohol misuse in transplantation of patients with alcohol disorders, people living with human immunodeficiency virus that need to adhere to ...
Radu M. Nanau, Manuela G. Neuman
doaj   +1 more source

In vitro fertilisation [PDF]

BMJ, 1988
H I, Abdalla, A, Kirkland, T, Leonard, P A, Stocker, R J, Baber, E C, Owen, J W, Studd   +6 more
openaire   +3 more sources

Penyimpanan in Vitro Tanaman Obat Daun Dewa Melalui Pertumbuhan Minimal [PDF]

, 2005
Daun dewa (Gynura Procumbens) is a medicinal crop commonly used to remedy cancer, diabetes, and dermatitis. It has a bright prospect for future used. Plant preservations through tissue culture is done to anticipate an urgent need.
Lestari, E. G. (Endang), Purnamaningsih, R. (Ragapadmi)   +1 more
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

ACTION OF SERUM ON LYMPHOCYTES IN VITRO [PDF]

, 1923
Alexis Carrel, Albert H. Ebeling
openalex   +1 more source

Green synthesis of silver nanoparticles using the plant extract of Salvia spinosa grown in vitro and their antibacterial activity assessment

Journal of Nanostructure in Chemistry, 2018
Researchers use bionanotechnology techniques as eco-friendly and cost-effective routes to fabricate nanoparticles and nanomaterials. The present study confirms the ability of plant extract of Salvia spinosa grown under in vitro condition for the ...
Saba Pirtarighat, M. Ghannadnia, S. Baghshahi   +2 more
semanticscholar   +1 more source