Results 111 to 120 of about 5,914,882 (359)

A human relevant in vitro alveolar epithelial barrier model to assess inhaled pollutant hazard

Scientific Reports
Relevant in vitro models could reduce the requirement for in vivo testing and allow higher throughput for imperative toxicological or pharmaceutical hazard testing.
Joshua W. P. Bateman, Kirsty Meldrum, Sarah M. Mitchell, Ulla Vogel, Martin J. D. Clift   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Extrusion pregelatinization improves texture, viscoelasticity and in vitro starch digestibility of mango and amaranth flours

, 2021
Daniel E. Garcia‐Valle, Edith Agama‐Acevedo, María del Carmen Núñez-Santiago, José Álvarez‐Ramírez, Luís A. Bello‐Pérez   +4 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

In Vitro Rooting of Poplar: Effects and Metabolism of Dichlorprop Auxin Ester Prodrugs

Plants
Efficient adventitious root formation is essential in micropropagation. Auxin prodrugs, inactive precursors that convert into active auxins within the plant, offer potentially improved rooting control and reduced phytotoxicity.
Hajer Darouez, Stefaan P. O. Werbrouck
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Molecular Identification of Human and Plant Pathogens in Municipal Domestic Wastewater for Hydroponic System Applications

International Journal of Microbiology
Water is essential for human survival and socioeconomic development, yet its overconsumption threatens global food security and ecosystem integrity. This necessitates a 60% increase in food production, further straining water resources.
Lukas Simon Kriem, Neil King, Sinja Niemann, Yevhen Vainshtein, Mirko Sonntag   +4 more
doaj   +1 more source

Beyond Conventional Auxins: Evaluating DCPE and DCP Pulse Applications for Enhanced Rooting in Lavandula angustifolia Mill.

Agronomy
Efficient adventitious root formation is crucial for Lavandula angustifolia Mill. propagation. This study evaluated the effects of continuous and short-duration pulse applications (1 min, 1 h, and 1 day) of the auxin dichlorprop (DCP) and its prodrug ...
Hajer Darouez, Stefaan P. O. Werbrouck
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Macrophages clear out necrotic liver lesions: a new magic trick revealed

eGastroenterology, 2023
Robim M Rodrigues, Joost Boeckmans, Tamara Vanhaecke   +2 more
doaj   +1 more source