Results 121 to 130 of about 6,403,737 (347)

Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions

Biomolecules, 2015
Background: The quantitative, measurable detection of drinking is important for the successful treatment of alcohol misuse in transplantation of patients with alcohol disorders, people living with human immunodeficiency virus that need to adhere to ...
Radu M. Nanau, Manuela G. Neuman
doaj   +1 more source

Cost-effective and eco-friendly synthesis of titanium dioxide (TiO₂) nanoparticles using fruit’s peel agro-waste extracts: characterization,in vitroantibacterial, antioxidant activities [PDF]

, 2019
Noushin Ajmal, Keerti Saraswat, Md. Afroz Bakht, Yassine Riadi, Mohamed Jawed Ahsan, Md. Noushad   +5 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Macrophages clear out necrotic liver lesions: a new magic trick revealed

eGastroenterology, 2023
Robim M Rodrigues, Joost Boeckmans, Tamara Vanhaecke   +2 more
doaj   +1 more source

Beyond Conventional Auxins: Evaluating DCPE and DCP Pulse Applications for Enhanced Rooting in Lavandula angustifolia Mill.

Agronomy
Efficient adventitious root formation is crucial for Lavandula angustifolia Mill. propagation. This study evaluated the effects of continuous and short-duration pulse applications (1 min, 1 h, and 1 day) of the auxin dichlorprop (DCP) and its prodrug ...
Hajer Darouez, Stefaan P. O. Werbrouck
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pengembangan Biakan In-vitro Plasmodium Falciparum secara Kontinu [PDF]

, 1994
To support malaria research on its' serology/immunology, chemotherapy, drug sensitivity aspects etc. especially for falciparum malaria, a large amount of antigen (parasites) is needed.
M, H. A. (Harijani), Suwarni, S. (Suwarni), Tuti, S. (Sekar)   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effects of anti-IL-4 receptor monoclonal antibody onin vitroT cell cytokine levels: IL-4 production by T cells from non-atopic donors [PDF]

, 1998
Dominique Bullens, Ahmad Kasran, Xiaohui Peng, K Lorré, Jan Ceuppens   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source