Results 71 to 80 of about 8,610,712 (380)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Hepatotoxicity of Pyrrolizidine Alkaloids

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: This article aimed 1) to review herbal medicine containing pyrrolizidine alkaloids (PA)-induced toxicities of the liver; 2) to encourage the recognition and prevention of common problems encountered when using complementary and alternative ...
Manuela G Neuman, Lawrence Cohen, Mihai Opris, Radu M Nanau, Hyunjin Jeong   +4 more
doaj   +1 more source

Kultur in Vitro Endosperma, Protokol Yang Efisien Untuk Mendapatkan Tanaman Triploid Secara Langsung [PDF]

, 2010
In Vitro Culture of Endosperm: An efficient protocol topropagate triploid plants directly. L. Agus Sukamto.Triploid plants are very vigorous and beneficial since theygenerally produce seedless fruits, bigger flowers, and producemore volume of wood than ...
Sukamto, L. A. (Lazarus)
core  

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Cell Death and Disease
Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases. However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS).
Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist   +5 more
doaj   +1 more source

In vitro Models of Neurodegenerative Diseases

Frontiers in Cell and Developmental Biology, 2020
Neurodegenerative diseases are progressive degenerative conditions characterized by the functional deterioration and ultimate loss of neurons. These incurable and debilitating diseases affect millions of people worldwide, and therefore represent a major ...
Anna Slanzi, Giulia Iannoto, Barbara Rossi, Elena Zenaro, G. Constantin   +4 more
semanticscholar   +1 more source

Konservasi in Vitro Tanaman Jeruk Besar (Citrus Maxima (Burm.) Merr.) Kultivar Srinyonya Menggunakan Osmotikum Dan Retardan [PDF]

, 2010
In Vitro Conservation of Pomelo (Citrus maxima (Burm.)Merr.) cv Srinyonya Using Osmoticum and Retardant.Iswari S. Dewi, Gani Jawak, Ika Roostika, M. Sabda,Bambang S. Purwoko, and Widiati H. Adil.
Adil, W. H. (Widiati), Dewi, I. S. (Iswari), Jawak, G. (Gani), Purwoko, B. S. (Bambang), Roostika, I. (Ika), Sabda, M. (Muhammad)   +5 more
core  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation

Toxics
Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also be induced by treating non-fibrotic hPCLS with a fibrotic cocktail (FC).
Méry Marimoutou, Vivek Patel, Jae Hun Kim, Niccole Schaible, Jose Alvarez, Joseph Hughes, McKenzie Obermok, Carlos Iván Rodríguez, Thomas Kallarakal, Béla Suki, Khalid Amin, Ramaswamy Krishnan, Holger Peter Behrsing   +12 more
doaj   +1 more source

Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma

Frontiers in Oncology, 2019
Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in foods such as coffee, wine, tea, and popular medicines such as propolis.
Kaio Murilo Monteiro Espíndola, Roseane Guimarães Ferreira, Luis Eduardo Mosquera Narvaez, Amanda Caroline Rocha Silva Rosario, Agnes Hanna Machado da Silva, Ana Gabrielle Bispo Silva, Ana Paula Oliveira Vieira, Marta Chagas Monteiro   +7 more
doaj   +1 more source