Results 71 to 80 of about 5,914,882 (359)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

open access: yesJournal of Experimental Medicine, 1998
Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens.
A. Thornton, E. Shevach
semanticscholar   +1 more source

Muscle stem cell isolation and in vitro culture for meat production: A methodological review.

open access: yesComprehensive Reviews in Food Science and Food Safety, 2020
Cultured muscle tissue-based protein products, also known as cultured meat, are produced through in vitro myogenesis involving muscle stem cell culture and differentiation, and mature muscle cell processing for flavor and texture.
Kwang-Hwan Choi   +7 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

open access: yesCell Death and Disease
Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases. However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS).
Markus Brüll   +5 more
doaj   +1 more source

AUTOSENSITIZATION IN VITRO [PDF]

open access: yesThe Journal of Experimental Medicine, 1971
Autosensitization of rat or mouse lymphoid cells against syngeneic fibroblast antigens was induced in cell culture. Rat lymphoid cells autosensitized by this method were able to produce immunospecific lysis of syngeneic target fibroblasts in vitro or GvH reactions in newborn rats.
Cohen, I R, Globerson, A, Feldman, M
openaire   +2 more sources

The legal status of in vitro embryos

open access: yes, 2014
Our science has advanced greatly and continues to do so. While being witnesses to this phenomenon, we are not yet ready to fully accept all of its results which can lead to the improvements of our biological structure, or our lives, in other words. There
Sandra Samardzic
semanticscholar   +1 more source

The Importance of Mechanical Forces for in vitro Endothelial Cell Biology

open access: yesFrontiers in Physiology, 2020
Blood and lymphatic vessels are lined by endothelial cells which constantly interact with their luminal and abluminal extracellular environments. These interactions confer physical forces on the endothelium, such as shear stress, stretch and stiffness ...
E. Gordon, L. Schimmel, Maike Frye
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern.
K. Kitaeva   +3 more
semanticscholar   +1 more source

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