Results 51 to 60 of about 670,418 (378)

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice [PDF]

, 2012
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing ...
Auburger, Georg, Azizov, Mekhman, Damrath, Ewa, Gispert, Suzana, Heck, Melanie V., Nowock, Joachim, Rüb, Udo, Seifried, Carola, Walter, Michael   +8 more
core   +3 more sources

Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak

Indian Journal of Ophthalmology, 2014
Context: Contrast sensitivity (CS) function is one of the most important tests available for evaluating visual impairment. Multiple sclerosis (MS) can produce highly selective losses in visual function and psychophysical studies have demonstrated CS ...
A F Nunes, P M L Monteiro, M Vaz Pato
doaj   +1 more source

Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Frontiers in Immunology, 2022
Natural killer cells constitute a part of the innate immune system that mediates an effective immune response towards virus-infected and malignant cells. In recent years, research has focused on exploring and advancing NK cells as an active immunotherapy
Mubin Tarannum, Rizwan Romee, Roman M. Shapiro   +2 more
doaj   +1 more source

Evolution of ASC Immunophenotypical Subsets During Expansion In Vitro [PDF]

International Journal of Molecular Sciences, 2020
Adipose-derived stromal/stem cells (ASCs) are currently being considered for clinical use for a number of indications. In order to develop standardized clinical protocols, it is paramount to have a full characterization of the stem cell preparations. The surface marker expression of ASCs has previously been characterized in multiple studies.
Qiuyue Peng, Hiva Alipour, Simone Porsborg, Trine Fink, Vladimir Zachar   +4 more
openaire   +3 more sources

Comparative evaluation of RetCam vs. gonioscopy images in congenital glaucoma

Indian Journal of Ophthalmology, 2014
Purpose: To compare clarity, exposure and quality of anterior chamber angle visualization in congenital glaucoma patients, using RetCam and indirect gonioscopy images. Design: Cross-sectional study Participants. Congenital glaucoma patients over age of 5
Raj V Azad, Parijat Chandra, Anuradha Chandra, Aparna Gupta, Viney Gupta, Ramanjit Sihota   +5 more
doaj   +1 more source

Persistent hepatitis C virus infection in vitro: coevolution of virus and host. [PDF]

, 2006
The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems.
Cheng, Guofeng, Chisari, Francis V, Chung, Josan, Gastaminza, Pablo, Isogawa, Masanori, McKeating, Jane A, Stamataki, Zania, Zhong, Jin   +7 more
core   +3 more sources

Making the switch: alternatives to foetal bovine serum for adipose-derived stromal cell expansion

Frontiers in Cell and Developmental Biology, 2016
Adipose-derived stromal cells (ASCs) are being used extensively in clinical trials. These trials require that ASCs are prepared using good manufacturing procedures (GMPs) and are safe for use in humans.
Carla Dessels, Marnie Potgieter, Marnie Potgieter, Michael Sean Pepper   +3 more
doaj   +1 more source

In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects

Cell Death and Disease, 2017
In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been approved for clinical application in stem cell-based treatment of cartilage defects. However, their chondrogenic potential has not yet been questioned or verified.
Tongmeng Jiang, Guojie Xu, Qiuyan Wang, Lihui Yang, Li Zheng, Jinmin Zhao, Xing‐dong Zhang   +6 more
semanticscholar   +1 more source

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

Science Translational Medicine, 2021
Description Small-molecule recruitment of an endogenous nuclease rescues pathologies associated with c9ALS/FTD in vivo by targeting an RNA repeat expansion.
Jessica A. Bush, Haruo Aikawa, R. Fuerst, Yue Li, Andrei Ursu, Samantha M. Meyer, Raphael I. Benhamou, Jonathan L Chen, Tanya Khan, Sarah Wagner-Griffin, M. V. Van Meter, Yuquan Tong, Hailey Olafson, Kendra K. McKee, Jessica L. Childs‐Disney, Tania F. Gendron, Yongjie Zhang, Alyssa N. Coyne, Eric T. Wang, Ilyas Yildirim, K. Wang, L. Petrucelli, J. Rothstein, M. Disney   +23 more
semanticscholar   +1 more source

Brachytherapy of intra ocular tumors using ′BARC I-125 Ocu-Prosta seeds′: An Indian experience

Indian Journal of Ophthalmology, 2014
Aim: To report our experience of brachytherapy using ′BARC I-125 Ocu-Prosta seeds′ for the management of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival at Sankara Nethralaya, Chennai, India ...
Vikas Khetan, Lingam Gopal, Mahesh P Shanmugam, Aditi Gupta, Tarun Sharma, Pramod Bhende, Siva Muthukumar, R Subramaniam, Thayalan Kuppuswamy, S K Saxena, Ashutosh Dash   +10 more
doaj   +1 more source