Results 191 to 200 of about 805,984 (229)

Determination of the apparent half-life of erythrocytes with radioactive 51Cr In vitro

Clinica Chimica Acta, 1961
Abstract The uptake of sodium chromate-51Cr by normal erythrocytes was estimated in relation to the number of red cells per μl. It is shown that the 51Cr uptake in a haemolytic syndrome—not associated with an antigen-antibody syndrome—is always increased compared to the 51Cr uptake in the same number of normal erythrocytes per μl. This quotient—the Q-
E, van KAMPEN, W, HEERSPINK
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Albumin-binding domain extends half-life of glucagon-like peptide-1.

European Journal of Pharmacology, 2020
Glucagon-like peptide-1 (GLP-1) is considered to be a promising peptide for the treatment of type 2 diabetes mellitus (T2DM). However, the extremely short half-life of GLP-1 limits its clinical application. Albumin-binding domain (ABD) with high affinity
Huanbo Tan, Wencheng Su, Wenyu Zhang, Jie Zhang, M. Sattler, P. Zou   +5 more
semanticscholar   +1 more source

In Vitro Studies on Physiological and Chemical Stability of New LE404-Derivatives with Extended Half-Life

Drug Research, 2018
AbstractDibenzoazecines are a class of potential neuroleptics with high affinity to dopamine and serotonin receptors. The efficacy and high therapeutic range has already been demonstrated in vivo with the lead structure 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol (LE404) and selected derivatives.
Stephanie, Zergiebel, Andreas, Seeling
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Effect of different conformations of galactose messenger RNA on gene expression and messenger half-life in vitro

Molecular and General Genetics MGG, 1975
From a DNA-directed cell-free system, functional gal mRNA is obtained which directs the cell-free synthesis of the three galactose enzymes of Escherichia coli. A substantial fraction of this gal mRNA has the properties of a polycistronic messenger.
G, Schumacher, R, Ehring
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In Vitro Effects of Cellular Phone Electromagnetic Fields at 940 MHz on the Structure and Half-Life of Recombinant Human Growth Hormone

Iranian Journal of Science and Technology, Transactions A: Science, 2020
The biological effects of non-ionizing electromagnetic radiation (EMF) are of high importance in biological and health studies. This study aimed to find out these effects on the structure and function of recombinant human growth hormone (rhGH). The rhGH was exposed to uniform mobile phone 940-MHz EMFs for 45 min and then characterized by circular ...
Mehdi Mohammadpour-Aghdam, Ahmad Molaeirad, Reza Faraji-Dana, Azadeh Azizi   +3 more
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Recombinant Fc-Elabela fusion protein has extended plasma half-life andmitigates post-infarct heart dysfunction in rats.

International Journal of Cardiology, 2019
Activation of the apelin receptor, or APJ, by apelin is considered a therapeutic avenue for cardiovascular disease, including heart failure. Recently, a novel endogenous ligand for APJ named Elabela (ELA) has been discovered and is known to possess anti ...
Yue Xi, Daozhan Yu, Rongze Yang, Qingbin Zhao, Junhong Wang, Hong Zhang, Kun Qian, Zhengrong Shi, Weimin Wang, Robert A. Brown, Yongxia Li, Zhenjun Tian, D. Gong   +12 more
semanticscholar   +1 more source

In vitro combined haemostatic efficacy of emicizumab and extended half‐life factor VIII compounds

Haemophilia
AbstractIntroductionEarly prophylaxis is the gold standard of care for severe haemophilia. The development of subcutaneous Factor VIII (FVIII) mimetics, such as emicizumab, has significantly reduced the disease burden and improved protection against bleeding episodes.
Laurie Josset, Hamdi Rezigue, Christophe Nougier, Alexandre Leuci, Stéphanie Désage, Anne Lienhart, Yesim Dargaud   +6 more
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Utilization of in vitro Caco‐2 permeability and liver microsomal half‐life screens in discovering BMS‐488043, a novel HIV‐1 attachment inhibitor with improved pharmacokinetic properties

Journal of Pharmaceutical Sciences, 2010
Optimizing pharmacokinetic properties to improve oral exposure is a common theme in modern drug discovery. In the present work, in vitro Caco-2 permeability and microsomal half-life screens were utilized in an effort to guide the structure-activity relationship in order to improve the pharmacokinetic properties of novel HIV-1 attachment inhibitors. The
Zheng, Yang, Lisa M, Zadjura, Anthony M, Marino, Celia J, D'Arienzo, Jacek, Malinowski, Christoph, Gesenberg, Pin-Fang, Lin, Richard J, Colonno, Tao, Wang, John F, Kadow, Nicholas A, Meanwell, Steven B, Hansel   +11 more
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Estimation of In Vivo Half‐Life From In Vitro Metabolic Clearance, Protein, and Cell Membrane Affinity Assays

ChemMedChem
A reliable prediction of the in vivo plasma half‐life of drug candidates, from easily accessible in vitro assays, is not yet possible. It is surmised that the existing models, which consider protein binding and metabolic clearance, will be improved if they also include the propensity of molecules to bind to cell membranes.
Carla Pou Miralbell, Sandrine Desrayaud, Berndt Oberhauser, John Reilly, Yves P. Auberson   +4 more
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In vitro metabolism of the synthetic cannabinoids PX-1, PX-2, and PX-3 by high resolution mass spectrometry and their clearance rates in human liver microsomes.

Rapid Communications in Mass Spectrometry, 2019
RATIONALE N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamine (PX-1), N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluropentyl)-1H-indazole-3-carboxamide (PX-2), and N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(cyclohexylmethyl)-1H-
Travon Cooman, S. Bell
semanticscholar   +1 more source