Results 151 to 160 of about 549,804 (200)

In Vitro/In Vivo Correlations

2000
While the main function of the skin is to protect an organism against dehydration and external stress, it is more or less permeable to some chemical substances and may allow the permeation of certain drugs for therapeutic purposes. The observation of professional intoxications challenged by this permeability has triggered research in this field ...
Eric Beyssac, J. M. Cardot, C. Bonnabry
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Correlation of in vivo and in vitro screening tests

Journal of Endodontics, 1978
In vitro experimentation presents advantages that include a higher degree of controlling test situations than currently used in in vivo experiments. The method is simple, inexpensive, and fast, and allows useful guidance during development of the material as well as control of production.
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Validation of in Vitro-in Vivo Correlation Models

1997
A valid model can be defined as one that is a) well-grounded on principles or evidence, b) able to withstand criticism or objection, and c) capable of serving the purpose of the model. In the area of mathematical modelling, there are two criteria in the validation process: internal criteria and external criteria (1). The internal criteria establish the
D, Young, J A, Dowell, D A, Piscitelli, J, Devane   +3 more
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In Vitro- In Vivo Correlation’s Dissolution Limits Setting

Pharmaceutical Research, 2014
In vitro in vivo correlation (IVIVC) is a biopharmaceutical tool recommended for use in formulation development. When validated, IVIVC can be used to set dissolution limits and, based on the dissolution limits, as a surrogate for an in vivo study.
B, Roudier, B M, Davit, E, Beyssac, J-M, Cardot   +3 more
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Correlation of In Vitro and In Vivo Methodology for Evaluation of Antacids

Journal of Pharmaceutical Sciences, 1976
The rate and extent of acid consumption of an antacid suspension and tablet were evaluated by in vitro and in vivo techniques. Four different test procedures were used to estimate in vitro antacid reactivity. In vivo effects were determined in the fasted and postcibal states in normal human subjects by a radiotelemetry procedure.
R D, Smyth, T, Herczeg, T A, Wheatley, W, Hause, N H, Reavey-Cantwell   +4 more
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Correlations of in vitro and in vivo hepatotoxicity for five haloalkanes

Toxicology and Applied Pharmacology, 1983
Five haloalkanes--CBrCl3, CCl4, CHCl3, and 1,1,1-and 1,1,2-trichloroethane (TCE)--were ranked for their relative hepatotoxicity in an in vitro system of isolated hepatocyte suspensions and in vivo by po administration of the test chemical to fasted rats of the same strain and sex as used for the hepatocytes. Cytotoxic parameters used for ranking in the
C A, Tyson, K, Hawk-Prather, D L, Story, D H, Gould   +3 more
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In Vitro-in Vivo Correlations

1997
Examples of in Vitro-in Vivo Relationships with a Diverse Range of Quality R.J. Rackley. Dissolution Assay Development for in Vitro-in Vivo Correlations: Theory and Case Studies B.R. Rohrs, et al. In Vitro Dissolution Profile Comparison and IVIVR: Carbamazepine Case P. Sathe, et al. A General Framework for Non-Parametric Subject-Specific and Population
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In vitro/in vivo correlations: Scientific implications and standardisation

European Journal of Drug Metabolism and Pharmacokinetics, 1993
In vitro/in vivo correlations and the parameters that should be correlated have now been well defined in the USP and FDA working group proposals. Among the three levels of correlation defined, Level A is the most interesting one. In this paper, the Level A correlation is studied from a mathematical and a biopharmaceutical point of view.
J M, Cardot, E, Beyssac
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Hyperthermia with implanted electrodes: In vitro and in vivo correlations

International Journal of Radiation Oncology*Biology*Physics, 1983
Hyperthermia as a treatment for cancer has elicited much recent interest. However, major difficulties persist both in the technology for heating deep-seated tumors, and in thermal dosimetry. We have investigated a heating technique for deep-seated neoplasms that employs an internal implanted electrode and an external electrode to apply radiofrequency ...
M B, Lilly, I A, Brezovich, W, Atkinson, D, Chakraborty, J R, Durant, J, Ingram, R B, McElvein   +6 more
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In Vitro–in Vivo Correlation of Mucoadhesion Studies on Buccal Mucosa

Molecular Pharmaceutics, 2019
For the development of novel buccoadhesive formulations, their physicochemical properties, strength of the interfacial joint, and residence time on the buccal mucosa are considered as a measure for their in vivo mucoadhesive properties. Focusing on these parameters, the predictive power of established in vitro systems was assessed for mucoadhesive ...
Randi Angela Baus, Michael Franz Haug, Christina Leichner, Max Jelkmann, Andreas Bernkop-Schnürch   +4 more
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