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In vitro-in vivo correlation of the pharmacokinetics of vinpocetine.
Polish journal of pharmacology, 2002Vinpocetine is extensively metabolized in rats, dogs and humans, and the plasma clearance approximates the hepatic plasma flow in each of the species. In vitro degradation studies with hepatocytes have shown that the activity of human hepatocytes is about one order of magnitude higher than the activity of dog hepatocytes, and two orders of magnitude ...
T, Szakács, Z, Veres, L, Vereczkey
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