Results 241 to 250 of about 114,426,039 (308)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

EFNA5 as an Oocyte-Derived Factor Enhances Developmental Competence by Modulating Oxidative Stress, Inflammation, and Apoptosis During In Vitro Maturation. [PDF]

Antioxidants (Basel)
Liu X, Cui J, Wang Y, Hao J, Wu Y, Wang Y, An L, Tian J, Xi G.   +8 more
europepmc   +1 more source

Oocyte in vitro maturation*

Current Trends in Clinical Embriology, 2015
openaire   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Effects of physiological oxygen tension on human cumulus-oocyte-complex metabolism during in vitro maturation: an exploratory study. [PDF]

J Ovarian Res
Anckaert E, Ates G, Liveyns A, Van Ranst H, Mostinckx L, Cools W, Mortier A, Massie A, De Vos M, Akin N.   +9 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation. [PDF]

Int J Mol Sci
Yeh LY, Chiu CS, Lee KS, Lee RK, Lin MH, Hwu YM, Li SH.   +6 more
europepmc   +1 more source

Cumulative live birth after unstimulated in vitro maturation versus conventional in vitro fertilization (IVF) in women with polycystic ovary syndrome: a 36-month retrospective matched cohort study. [PDF]

J Ovarian Res
Guo W, Chen L, Yang Z, Wang L, Wu H, Yang R, Yang S, Zheng X, Chang HM, Zhen X, Qiao J, Li R.   +11 more
europepmc   +1 more source

Does ovarian morphology type affect the reproductive outcomes of in-vitro maturation cycles in polycystic ovary syndrome? [PDF]

J Assist Reprod Genet
Hochberg A, Elizur S, Goorah B, Tannus S, Son WY, Dahan MH.   +5 more
europepmc   +1 more source

Rescue in vitro maturation of germinal vesicle oocytes after ovarian stimulation: the importance of the culture media. [PDF]

Hum Reprod
Soler N, Cimadomo D, Escrich L, Grau N, Galán A, Alamá P, de Los Santos MJ, Rienzi L, Escribá MJ.   +8 more
europepmc   +1 more source