FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
In vitro 3D liver tumor microenvironment models for immune cell therapy optimization [PDF]
, 2021 Maxine Lam +4 more
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering. [PDF]
J Biol Eng, 2018 Rijal G, Li W.
europepmc +1 more source
Skin-integrated melanoma organoids to study the tumor microenvironment-mediated mechanisms of melanoma progression and metastasis in vitro [PDF]
Gemma Nomdedeu‐Sancho +5 more
openalex +1 more source
N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: implications for breast cancer viability and proliferation in vitro [PDF]
, 2017 Brittany Balhouse +4 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
The synergistic effects of the RGD density and the microenvironment on the behavior of encapsulated cells:In vitroandin vivodirect comparative study [PDF]
, 2013 Edorta Santos‐Vizcaíno +4 more
openalex +1 more source
A 3D Biohybrid Real‐Scale Model of the Brain Cancer Microenvironment for Advanced In Vitro Testing [PDF]
, 2020 Omar Tricinci +5 more
openalex +1 more source