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In Vitro and Ex Vivo Models – The Tumor Microenvironment in a Flask
2020Experimental tumor modeling has long supported the discovery of fundamental mechanisms of tumorigenesis and tumor progression, as well as provided platforms for the development of novel therapies. Still, the attrition rates observed today in clinical translation could be, in part, mitigated by more accurate recapitulation of environmental cues in ...
Catarina, Pinto +2 more
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3D in vitro Models to Mimic the Tumor Microenvironment
2021A completely different approach to create a biologically relevant in vitro model is the culture of biological samples themselves in the form of tumor tissues or slices. In the recent years, two approaches have emerged more or less in parallel to create 3D in vitro models that are easy to control and reproduce while maintaining a high biological ...
Alexander, Marcel +3 more
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Modeling the chronic lymphocytic leukemia microenvironmentin vitro
Leukemia & Lymphoma, 2016Microenvironments within the lymph node and bone marrow promote proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Successful treatment of CLL must therefore target the leukemic cells within these compartments. A better understanding of the interaction between CLL cells and the tumor microenvironment has led to the development of ...
Kyle, Crassini +3 more
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Changes of microenvironment in an in vitro co-culture system
Italian Journal of Anatomy and Embryology, 2015For the enhanced understanding of fundamental cancer biology and improving molecular diagnostics and therapeutics, the role of the microenvironment during the initiation and progression of carcinogenesis is thought to be of critical importance (1, 2).
Salvatore, Viviana +5 more
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In vitro microenvironments to study breast cancer bone colonisation
Advanced Drug Delivery Reviews, 2014Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood.
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Cell microenvironment and carcinogenesis in vivo and in vitro.
IARC scientific publications, 1984Normal cells of many types are located in vivo and in vitro at the boundary between the two compartments of their microenvironment: between the noncellular surface (artificial substrates and cell-made matrices) and the humoral medium. Altered reactions to both these parts of microenvironment and to neighbouring cells are characteristic of neoplastic ...
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Haemopoietic microenvironments in vitro: ultrastructural aspects.
Ciba Foundation symposium, 1981Haemopoietically active long-term bone marrow cultures from several species have been investigated ultrastructurally. Human, tree shrew and mouse cultures generally support granulopoiesis, although recently it has been possible to convert a granulopoietic mouse culture to extensive erythropoiesis.
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Microfluidic device for recreating a tumor microenvironment in vitro.
Journal of visualized experiments : JoVE, 2012We have developed a microfluidic device that mimics the delivery and systemic clearance of drugs to heterogeneous three-dimensional tumor tissues in vitro. Nutrients delivered by vasculature fail to reach all parts of tumors, giving rise to heterogeneous microenvironments consisting of viable, quiescent and necrotic cell types.
Bhushan J, Toley +3 more
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