Results 1 to 10 of about 1,293,967 (118)
Viruses, 2021 The emergence and rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in vitro and in vivo models that could be applied in COVID-19 research.
Rafael B. Rosa +5 more
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An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma [PDF]
Cancer MedicineBackground Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol‐related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and ...
Anoïsia Courtois +5 more
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The impact of percutaneous epididymal sperm aspiration on sperm quality in mice
Reproduction and Fertility, 2023 In laboratory mice, sperm quality is usually assessed in spermatozoa collected from the cauda epididymidis of freshly sacrificed males. Percutaneous epididymal sperm aspiration (PESA) is a non-terminal alternative that would allow repeated sperm ...
Lisa Windhofer +4 more
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Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice
Reproductive Medicine and Biology, 2022 Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma +8 more
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Mate genetic similarity affects mating behaviour but not maternal investment in mice
Scientific Reports, 2023 Maternal investment can affect the survival and development of offspring. Here we experimentally investigated in mice, whether females alter implantation rates and pup survival after embryo transfer depending on the genetic similarity with their ...
Kerstin E. Auer +4 more
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Effects of diclofenac on sentinel species and aquatic communities in semi-natural conditions
Ecotoxicology and Environmental Safety, 2021 Due to the potential hazard of diclofenac on aquatic organisms and the lack of higher-tier ecotoxicological studies, a long-term freshwater mesocosm experiment was set up to study the effects of this substance on primary producers and consumers at ...
S. Joachim +17 more
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Molecular Oncology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects
Kathrin Hedegger +7 more
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Animals, 2022 Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under discussion which temperature is more appropriate and whether the commonly used room temperature in ...
Thomas Kolbe +5 more
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Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Frontiers in Bioengineering and Biotechnology, 2020 Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and disease hold great promise for improving fundamental research, drug ...
Clare L. Thompson +4 more
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Emerging cancer models for drugs and novel dosages development [PDF]
World Cancer Research Journal, 2022 Objective: Cancer is the primary cause of death all over the world, despite of its early detection and novel therapies available. The process of cancer drug development is growing tremendously.
P. Das, M. Das
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