Results 1 to 10 of about 1,346,069 (268)
The impact of percutaneous epididymal sperm aspiration on sperm quality in mice
Reproduction and Fertility, 2023 In laboratory mice, sperm quality is usually assessed in spermatozoa collected from the cauda epididymidis of freshly sacrificed males. Percutaneous epididymal sperm aspiration (PESA) is a non-terminal alternative that would allow repeated sperm ...
Lisa Windhofer +4 more
doaj +1 more source
Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice
Reproductive Medicine and Biology, 2022 Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma +8 more
doaj +1 more source
Mate genetic similarity affects mating behaviour but not maternal investment in mice
Scientific Reports, 2023 Maternal investment can affect the survival and development of offspring. Here we experimentally investigated in mice, whether females alter implantation rates and pup survival after embryo transfer depending on the genetic similarity with their ...
Kerstin E. Auer +4 more
doaj +1 more source
Effects of diclofenac on sentinel species and aquatic communities in semi-natural conditions
Ecotoxicology and Environmental Safety, 2021 Due to the potential hazard of diclofenac on aquatic organisms and the lack of higher-tier ecotoxicological studies, a long-term freshwater mesocosm experiment was set up to study the effects of this substance on primary producers and consumers at ...
S. Joachim +17 more
doaj +1 more source
Molecular Oncology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects
Kathrin Hedegger +7 more
doaj +1 more source
Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Frontiers in Bioengineering and Biotechnology, 2020 Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and disease hold great promise for improving fundamental research, drug ...
Clare L. Thompson +4 more
doaj +1 more source
Animals, 2022 Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under discussion which temperature is more appropriate and whether the commonly used room temperature in ...
Thomas Kolbe +5 more
doaj +1 more source
Emerging cancer models for drugs and novel dosages development [PDF]
World Cancer Research Journal, 2022 Objective: Cancer is the primary cause of death all over the world, despite of its early detection and novel therapies available. The process of cancer drug development is growing tremendously.
P. Das, M. Das
doaj +1 more source
In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview
Frontiers in Oncology, 2021 After leukemia, tumors of the brain and spine are the second most common form of cancer in children. Despite advances in treatment, brain tumors remain a leading cause of death in pediatric cancer patients and survivors often suffer from life-long ...
Zhiqin Li, Sigrid A. Langhans
doaj +1 more source
Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases
Pharmaceutics, 2023 Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative perturbations in the intracellular microenvironment constitutively controlled by glutathione peroxidase 4 (GPX4).
Inês Costa +6 more
doaj +1 more source