Results 31 to 40 of about 1,294,116 (267)
An In Vitro Model for Thyroid Autoimmunity [PDF]
, 1987 Clinical observations have suggested an association between iodine intake and the occurance of autoimmune thyroiditis in man (1,2), while in areas with endemic goiter prevalence due to iodine deficiency a lower incident of Hashimoto’s thyroditis was found (3), Others, however, have contested these claims (4,5). Experimentally, this association has been
Wenzel, B. E. +3 more
openaire +2 more sources
Sixth European Seminar in Virology on Virus–Host Interaction at Single Cell and Organism Level
Viruses, 2018 The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22–24 June 2018, and brought together international scientists and young researchers working in the field of Virology.
Elisa Saccon +4 more
doaj +1 more source
The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval
Cells, 2021 Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and
Mariana Matias +5 more
doaj +1 more source
In Vitro Microscale Models for Embryogenesis
Advanced Biosystems, 2018 AbstractEmbryogenesis is a highly regulated developmental process requiring complex mechanical and biochemical microenvironments to give rise to a fully developed and functional embryo. Significant efforts are taken to recapitulate specific features of embryogenesis by presenting the cells with developmentally relevant signals.
Jennifer Rico‐Varela +2 more
openaire +3 more sources
In vitro models for investigating itch
Frontiers in Molecular Neuroscience, 2022 Itch (pruritus) is a sensation that drives a desire to scratch, a behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch is a hallmark symptom and in which prolonged scratching can induce damage.
Hendrik Mießner +3 more
openaire +3 more sources
An In Vitro Model of Fabry Disease [PDF]
Journal of the American Society of Nephrology, 2005 Fabry disease is an X-linked inherited loss of alpha-galactosidase A (alpha-Gal A). Affected patients experience complications that include neuropathy, renal failure, and cardiovascular disease. Although the genetic and biochemical basis of this sphingolipidosis is well studied, the basis for the vascular disease remains poorly understood.
Liming, Shu +3 more
openaire +2 more sources
In vitro models of intracerebral hemorrhage
Brain Hemorrhages, 2022 Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research.
Bilal Syed, Abhijit Nirwane, Yao Yao
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Role of the osteocyte in bone metastasis – The importance of networking
Journal of Bone OncologyMetastatic bone disease is a complex condition resulting from the migration and colonization of cancer cells from their primary site to the bone microenvironment, where they typically develop a metastatic niche.
Stefaan W. Verbruggen
doaj +1 more source