Results 31 to 40 of about 1,296,513 (265)
The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval
Cells, 2021 Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and
Mariana Matias +5 more
doaj +1 more source
An In Vitro Model for Thyroid Autoimmunity [PDF]
, 1987 Clinical observations have suggested an association between iodine intake and the occurance of autoimmune thyroiditis in man (1,2), while in areas with endemic goiter prevalence due to iodine deficiency a lower incident of Hashimoto’s thyroditis was found (3), Others, however, have contested these claims (4,5). Experimentally, this association has been
Wenzel, B. E. +3 more
openaire +2 more sources
In Vitro Microscale Models for Embryogenesis
Advanced Biosystems, 2018 AbstractEmbryogenesis is a highly regulated developmental process requiring complex mechanical and biochemical microenvironments to give rise to a fully developed and functional embryo. Significant efforts are taken to recapitulate specific features of embryogenesis by presenting the cells with developmentally relevant signals.
Jennifer Rico‐Varela +2 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
In vitro models for investigating itch
Frontiers in Molecular Neuroscience, 2022 Itch (pruritus) is a sensation that drives a desire to scratch, a behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch is a hallmark symptom and in which prolonged scratching can induce damage.
Hendrik Mießner +3 more
openaire +3 more sources
Role of the osteocyte in bone metastasis – The importance of networking
Journal of Bone OncologyMetastatic bone disease is a complex condition resulting from the migration and colonization of cancer cells from their primary site to the bone microenvironment, where they typically develop a metastatic niche.
Stefaan W. Verbruggen
doaj +1 more source
Basic & Clinical Cancer Research, 2019 Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in hyperthermia, the use of magnetic nanoparticles is suggested.
Zahra Zahedi-Tabar +3 more
doaj +1 more source
Experimental Models as Refined Translational Tools for Breast Cancer Research
Scientia Pharmaceutica, 2020 Breast cancer is one of the most common cancers worldwide, which makes it a very impactful malignancy in the society. Breast cancers can be classified through different systems based on the main tumor features and gene, protein, and cell receptors ...
Eduardo Costa +5 more
doaj +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source