Results 21 to 30 of about 1,346,069 (268)
Animals, 2022 In vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and their use has failed to identify novel therapies effective for many highly prevalent non ...
Laura Gribaldo, Adelaide Dura
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In vitro models of axon regeneration [PDF]
Experimental Neurology, 2017 A variety of in vitro models have been developed to understand the mechanisms underlying the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical development of regeneration-promoting therapeutics. These range from single-cell based assays that typically focus on molecular mechanisms to organotypic assays that aim to ...
Hassan, Al-Ali +3 more
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Molecular Oncology, 2021 The incidence of melanoma and nonmelanoma skin cancer has increased tremendously in recent years. Although novel treatment options have significantly improved patient outcomes, the prognosis for most patients with an advanced disease remains dismal.
Christine Hoesl +6 more
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Journal of Investigative Dermatology, 1996 To help elucidate the factors responsible for the infundibular changes seen in acne, the human sebaceous pilosebaceous infundibulum was isolated by microdissection and maintained for 7 d in keratinocyte serum-free medium supplemented with 50 micrograms/ml bovine pituitary extract, 100 units/ml penicillin and streptomycin, 2.5 micrograms/ml amphotericin
Guy, Robert +2 more
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An in vitro model of neuronal ensembles
Nature Communications, 2022 AbstractAdvances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and developmental mechanisms underlying brain diseases. However, their efficacy in recapitulating brain network properties that encode brain function remains limited, thereby precluding ...
M. Angeles Rabadan +10 more
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Ischemic Stroke, Lessons from the Past towards Effective Preclinical Models
Biomedicines, 2022 Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far, approved therapies rely on reperfusion of the affected brain area, by intravenous thrombolysis or mechanical thrombectomy.
Beatriz Amado +5 more
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Viruses, 2021 The emergence and rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in vitro and in vivo models that could be applied in COVID-19 research.
Rafael B. Rosa +5 more
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Fracture Healing Research—Shift towards In Vitro Modeling?
Biomedicines, 2021 Fractures are one of the most frequently occurring traumatic events worldwide. Approximately 10% of fractures lead to bone healing disorders, resulting in strain for affected patients and enormous costs for society. In order to shed light into underlying
Moritz Pfeiffenberger +5 more
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Sixth European Seminar in Virology on Virus–Host Interaction at Single Cell and Organism Level
Viruses, 2018 The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22–24 June 2018, and brought together international scientists and young researchers working in the field of Virology.
Elisa Saccon +4 more
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The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval
Cells, 2021 Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and
Mariana Matias +5 more
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