Results 21 to 30 of about 1,294,116 (267)
In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia
Biomolecules, 2020 Schizophrenia (SZ) is a complex psychiatric disorder characterized by positive, negative, and cognitive symptoms, and is not satisfactorily treated by current antipsychotics.
Oliwia Koszła +3 more
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Nanomaterials, 2022 The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized.
Valérie Forest
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Stem Cells, 2012 Abstract The current resurgence of interest in the cancer stem cell (CSC) hypothesis as possibly providing a unifying theory of cancer biology is fueled by the growing body of work on normal adult tissue stem cells and the promise that CSC may hold the key to one of the central problems of clinical oncology: tumor recurrence.
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Animals, 2022 In vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and their use has failed to identify novel therapies effective for many highly prevalent non ...
Laura Gribaldo, Adelaide Dura
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An in vitro model of neuronal ensembles
Nature Communications, 2022 AbstractAdvances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and developmental mechanisms underlying brain diseases. However, their efficacy in recapitulating brain network properties that encode brain function remains limited, thereby precluding ...
M. Angeles Rabadan +10 more
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Journal of Investigative Dermatology, 1996 To help elucidate the factors responsible for the infundibular changes seen in acne, the human sebaceous pilosebaceous infundibulum was isolated by microdissection and maintained for 7 d in keratinocyte serum-free medium supplemented with 50 micrograms/ml bovine pituitary extract, 100 units/ml penicillin and streptomycin, 2.5 micrograms/ml amphotericin
Guy, Robert +2 more
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Molecular Oncology, 2021 The incidence of melanoma and nonmelanoma skin cancer has increased tremendously in recent years. Although novel treatment options have significantly improved patient outcomes, the prognosis for most patients with an advanced disease remains dismal.
Christine Hoesl +6 more
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Ischemic Stroke, Lessons from the Past towards Effective Preclinical Models
Biomedicines, 2022 Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far, approved therapies rely on reperfusion of the affected brain area, by intravenous thrombolysis or mechanical thrombectomy.
Beatriz Amado +5 more
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An In Vitro Model of Glioma Development
Genes, 2023 Gliomas are the prevalent forms of brain cancer and derive from glial cells. Among them, astrocytomas are the most frequent. Astrocytes are fundamental for most brain functions, as they contribute to neuronal metabolism and neurotransmission. When they acquire cancer properties, their functions are altered, and, in addition, they start invading the ...
Gabriella Schiera +14 more
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Fracture Healing Research—Shift towards In Vitro Modeling?
Biomedicines, 2021 Fractures are one of the most frequently occurring traumatic events worldwide. Approximately 10% of fractures lead to bone healing disorders, resulting in strain for affected patients and enormous costs for society. In order to shed light into underlying
Moritz Pfeiffenberger +5 more
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