Results 1 to 10 of about 1,309,212 (118)
In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia
Biomolecules, 2020 Schizophrenia (SZ) is a complex psychiatric disorder characterized by positive, negative, and cognitive symptoms, and is not satisfactorily treated by current antipsychotics.
Oliwia Koszła +3 more
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Viruses, 2021 The emergence and rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in vitro and in vivo models that could be applied in COVID-19 research.
Rafael B. Rosa +5 more
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The impact of percutaneous epididymal sperm aspiration on sperm quality in mice
Reproduction and Fertility, 2023 In laboratory mice, sperm quality is usually assessed in spermatozoa collected from the cauda epididymidis of freshly sacrificed males. Percutaneous epididymal sperm aspiration (PESA) is a non-terminal alternative that would allow repeated sperm ...
Lisa Windhofer +4 more
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Scientific Reports, 2021 Phenylketonuria (PKU) is an autosomal recessive inborn error of l-phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the enzyme phenylalanine hydroxylase (PAH), which is necessary for conversion of Phe to tyrosine (Tyr ...
Kuldeep Singh +21 more
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Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice
Reproductive Medicine and Biology, 2022 Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma +8 more
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Mate genetic similarity affects mating behaviour but not maternal investment in mice
Scientific Reports, 2023 Maternal investment can affect the survival and development of offspring. Here we experimentally investigated in mice, whether females alter implantation rates and pup survival after embryo transfer depending on the genetic similarity with their ...
Kerstin E. Auer +4 more
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npj Vaccines, 2021 Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previous BCG vaccination and (ii) be directed against Mycobacterium tuberculosis (Mtb) proteins expressed throughout the Mtb infection-cycle.
Mariateresa Coppola +7 more
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Effects of diclofenac on sentinel species and aquatic communities in semi-natural conditions
Ecotoxicology and Environmental Safety, 2021 Due to the potential hazard of diclofenac on aquatic organisms and the lack of higher-tier ecotoxicological studies, a long-term freshwater mesocosm experiment was set up to study the effects of this substance on primary producers and consumers at ...
S. Joachim +17 more
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Molecular Oncology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects
Kathrin Hedegger +7 more
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Alzheimer’s Research & Therapy, 2022 Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge +7 more
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