Results 31 to 40 of about 1,364,664 (267)
Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases
Pharmaceutics, 2023 Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative perturbations in the intracellular microenvironment constitutively controlled by glutathione peroxidase 4 (GPX4).
Inês Costa +6 more
doaj +1 more source
Modelling neuroinflammatory phenotypes in vivo.
Journal of neuroinflammation, 2004 Inflammation of the central nervous system is an important but poorly understood part of neurological disease. After acute brain injury or infection there is a complex inflammatory response that involves activation of microglia and astrocytes and increased production of cytokines, chemokines, acute phase proteins, and complement factors. Antibodies and
Wyss-Coray Tony, Buckwalter Marion S
openaire +3 more sources
WFUMB Ultrasound OpenCardiac dysfunction is a common feature of numerous diseases, ranging from metabolic disorders like Mucopolysaccharidosis Type 1 (MPS I), a.k.a. Hurler syndrome to neuromuscular disorders such as Myotonic Dystrophy type 1 (DM1).
James Cao +8 more
doaj +1 more source
Modeling Parkinson’s Disease: Not Only Rodents?
Frontiers in Aging Neuroscience, 2021 Parkinson’s disease (PD) is a common chronic progressive multifactorial neurodegenerative disease. In most cases, PD develops as a sporadic idiopathic disease.
Maria Shadrina, Petr Slominsky
doaj +1 more source
Models for Studying Angiogenesis in Vivo
The International Journal of Biological Markers, 1999 In vivo and in vitro techniques are available for reseach on the functions of endothelial cells during angiogenesis. In this review we describe and evaluate the methodology and specific features of some of the most frequently used in vivo assays.
RIBATTI, Domenico, VACCA, Angelo
openaire +2 more sources
Ischemic Stroke, Lessons from the Past towards Effective Preclinical Models
Biomedicines, 2022 Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far, approved therapies rely on reperfusion of the affected brain area, by intravenous thrombolysis or mechanical thrombectomy.
Beatriz Amado +5 more
doaj +1 more source
In Vivo Model of Small Intestine [PDF]
, 2017 The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases.
Maxime M, Mahe +3 more
openaire +2 more sources
Sixth European Seminar in Virology on Virus–Host Interaction at Single Cell and Organism Level
Viruses, 2018 The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22–24 June 2018, and brought together international scientists and young researchers working in the field of Virology.
Elisa Saccon +4 more
doaj +1 more source
Fracture Healing Research—Shift towards In Vitro Modeling?
Biomedicines, 2021 Fractures are one of the most frequently occurring traumatic events worldwide. Approximately 10% of fractures lead to bone healing disorders, resulting in strain for affected patients and enormous costs for society. In order to shed light into underlying
Moritz Pfeiffenberger +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source