Results 51 to 60 of about 1,321,319 (311)
Fracture Healing Research—Shift towards In Vitro Modeling?
Biomedicines, 2021 Fractures are one of the most frequently occurring traumatic events worldwide. Approximately 10% of fractures lead to bone healing disorders, resulting in strain for affected patients and enormous costs for society. In order to shed light into underlying
Moritz Pfeiffenberger +5 more
doaj +1 more source
A Model for the Action of Vinblastine in Vivo
Biophysical Journal, 1966 A model for the action of vinblastine (VLB) on cells multiplying exponentially in vivo with a generation time, T(G), has been derived. It is based on the assumption that cells attempting to pass through mitosis in the presence of VLB lose their proliferative capacity and that this lethal effect occurs only when the cells are exposed to a concentration ...
Valeriote, F.A. +2 more
openaire +2 more sources
Modeling Melanoma In Vitro and In Vivo [PDF]
Healthcare, 2013 The behavior of melanoma cells has traditionally been studied in vitro in two-dimensional cell culture with cells adhering to plastic dishes. However, in order to mimic the three-dimensional architecture of a melanoma, as well as its interactions with the tumor microenvironment, there has been the need for more physiologically relevant models.
Beaumont, Kimberley A. +2 more
openaire +5 more sources
The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval
Cells, 2021 Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and
Mariana Matias +5 more
doaj +1 more source
Critical sized mandibular defect regeneration in preclinical in vivo models
, 2016 Restoration of critical sized defects of the mandible still poses a major problem in the field of Oral and Maxillofacial Surgery. The current gold standard of treatment relies on the use of autologous grafts and therefore, has associated disadvantages ...
Woodruff, M.A. +3 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Experimental Models for Fungal Keratitis: An Overview of Principles and Protocols
Cells, 2020 Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of ...
Micaela L. Montgomery, Kevin K. Fuller
doaj +1 more source
Computational, In Vitro, and In Vivo Models for Nose-to-Brain Drug Delivery Studies
Biomedicines, 2023 Direct nose-to-brain drug delivery offers the opportunity to treat central nervous system disorders more effectively due to the possibility of drug molecules reaching the brain without passing through the blood–brain barrier. Such a delivery route allows
Radka Boyuklieva +2 more
doaj +1 more source
Modeling protein folding in vivo [PDF]
Biology Direct, 2018 A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways.
Irina Sorokina, Arcady Mushegian
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source