Results 61 to 70 of about 1,364,664 (267)

In vivo wireless channel modeling [PDF]

, 2016
25 pages, 17 figures, 7 tables, URL of the final version: https://digital-library.theiet.org/content/books/10.1049/pbte065e_ch7 .
Demir, Ali Fatih, Ankaralı, Zekeriyya Esat, Liu, Yang, Abbasi, Qammer Hussain, Qaraqe, Khalid, Serpedin, Erchin, Arslan, Hüseyin, Gitlin, Richard   +7 more
openaire   +3 more sources

The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents

Scientific Reports, 2018
Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (AEA ...
Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Valérie Fauchey, Franck Slowinski, Philippe Pichat, Gihad Dargazanli, Ahmed Abouabdellah, Caroline Cohen, Olivier E. Bergis   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity

mBio
Rickettsia parkeri is an obligate intracellular, tick-borne bacterial pathogen that can cause eschar-associated rickettsiosis in humans. R. parkeri invades host cells, escapes from vacuoles into the cytosol, and undergoes two independent modes of actin ...
Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Digital pathology and artificial intelligence in veterinary medicine

Brazilian Journal of Veterinary Pathology
This review discusses the benefits and limitations of using digital pathology and artificial intelligence in veterinary pathology. Digital pathology has the potential to build a global community of pathologists as it promotes communication and ...
Camila Issa Amaral, Ingeborg Maria Langohr, Paula Roberta Giaretta, Roselene Ecco   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Advances in androgenetic alopecia model research

Frontiers in Pharmacology
Androgenetic alopecia (AGA) is the most prevalent form of non-scarring hair loss, and its pathogenesis is quite complex, involving androgen metabolism, follicular microenvironment imbalance, oxidative stress, and inflammatory responses.
Mingrui Zhang, Guiyun Zhang, Wensi Zhang, Yihe Zhang, Yangchun Xu   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Review on the Application of In Vitro and In Vivo Models of Cancerous Tumors for the Study of the Hyperthermia Effect

Basic & Clinical Cancer Research, 2019
Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in  hyperthermia, the use of magnetic nanoparticles is suggested.
Zahra Zahedi-Tabar, Shadab Bagheri-Khoulenjani, Saeid Amanpour, Hamid Mirzadeh   +3 more
doaj   +1 more source