Results 61 to 70 of about 1,321,319 (311)

DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity

, 2022
All data in Excel spreadsheets for numbered figures in DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis ...
Hodge, James, Parsons, Tom, Zhu, Bangfu
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

mAbs
Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology.
Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou   +11 more
doaj   +1 more source

Experimental models of tumor growth in soft tissue sarcomas

RUDN Journal of Medicine, 2023
Soft tissue sarcomas are rare tumors (about 1 % of all malignant neoplasms) and include more than 70 histological subtypes, the pathogenetic features of which remain unclear.
Mariia S. Tretyakova, Ustinya A. Bokova, Anastasia A. Korobeynikova, Evgeny V. Denisov   +3 more
doaj   +1 more source

In vivo wireless channel modeling [PDF]

, 2016
25 pages, 17 figures, 7 tables, URL of the final version: https://digital-library.theiet.org/content/books/10.1049/pbte065e_ch7 .
Demir, Ali Fatih, Ankaralı, Zekeriyya Esat, Liu, Yang, Abbasi, Qammer Hussain, Qaraqe, Khalid, Serpedin, Erchin, Arslan, Hüseyin, Gitlin, Richard   +7 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity

, 2006
in vivo models of ...
Changlian Zhu, Beek, Johan van, Zhu, Changlian,, Johan Van Beek, Blomgren, Klas, van Beek, J., Blomgren, Klas,, Leist, Marcel, Leist, M., Marcel Leist, Christiane Volbracht, Zhu, Changlian, Volbracht, C., Klas Blomgren, Volbracht, Christiane   +14 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development

, 2016
Development of novel drugs for treatment of chronic inflammatory diseases is to a large extent dependent on the availability of good experimental in vivo models in order to perform preclinical tests of new drugs and for the identification of novel drug ...
Samra Sardar, Andersson, Åsa, Sardar, Samra,, Sardar, Samra, Åsa Andersson, Andersson, Åsa,   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source