Results 21 to 30 of about 1,311,826 (266)
In vivo Pooled Screening: A Scalable Tool to Study the Complexity of Aging and Age-Related Disease
Frontiers in Aging, 2021 Biological aging, and the diseases of aging, occur in a complex in vivo environment, driven by multiple interacting processes. A convergence of recently developed technologies has enabled in vivo pooled screening: direct administration of a library of ...
Martin Borch Jensen +2 more
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In Vivo Facilitated Diffusion Model
PLoS ONE, 2013 Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed.
Bauer, Maximilian +1 more
openaire +5 more sources
Molecular Therapy: Methods & Clinical Development, 2020 Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of ...
Tuan-Minh Do +25 more
doaj +1 more source
Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig
Antioxidants, 2021 Oxidative stress is directly linked to non-alcoholic fatty liver disease (NAFLD) and the progression to steaotohepatitis (NASH). Thus, a beneficial role of antioxidants in delaying disease progression and/or accelerating recovery may be expected, as ...
Josephine Skat-Rørdam +8 more
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Animals, 2022 Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under discussion which temperature is more appropriate and whether the commonly used room temperature in ...
Thomas Kolbe +5 more
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Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D
Frontiers in Cellular and Infection Microbiology, 2022 Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second most common sexually transmitted infection worldwide. Disease progression, drug discovery, and basic host-pathogen interactions are studied using different approaches ...
Motaharehsadat Heydarian +3 more
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Frontiers in Veterinary Science, 2021 Neospora caninum and Toxoplasma gondii are one of the main concerns of the livestock sector as they cause important economic losses in ruminants due to the reproductive failure.
Iván Pastor-Fernández +4 more
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Nanomaterials, 2022 The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized.
Valérie Forest
doaj +1 more source
Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases
Pharmaceutics, 2023 Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative perturbations in the intracellular microenvironment constitutively controlled by glutathione peroxidase 4 (GPX4).
Inês Costa +6 more
doaj +1 more source
In Vivo Model of Small Intestine [PDF]
, 2017 The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases.
Maxime M, Mahe +3 more
openaire +2 more sources