Results 21 to 30 of about 1,321,319 (311)

In vivo Pooled Screening: A Scalable Tool to Study the Complexity of Aging and Age-Related Disease

Frontiers in Aging, 2021
Biological aging, and the diseases of aging, occur in a complex in vivo environment, driven by multiple interacting processes. A convergence of recently developed technologies has enabled in vivo pooled screening: direct administration of a library of ...
Martin Borch Jensen, Adam Marblestone, Adam Marblestone   +2 more
doaj   +1 more source

In Vivo Facilitated Diffusion Model

PLoS ONE, 2013
Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed.
Bauer, Maximilian, Metzler, Ralf (Prof. Dr.)   +1 more
openaire   +5 more sources

Lymphangiogenesis: in vitro and in vivo models [PDF]

, 2010
peer reviewedLymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft rejection.
Noël, Agnès, Bruyère, Françoise
core   +1 more source

In vivo models of Escherichia coli infection in poultry

, 2022
Escherichia coli represents a significant challenge to the poultry industry due to compromised animal welfare, vast productivity losses, elevated mortality, and increased use of antimicrobial compounds.
Jensen, Henrik Elvang, Kromann, Sofie
core   +1 more source

Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models [PDF]

, 2014
Background: Zebrafish is a clinically-relevant model of heart regeneration. Unlike mammals, it has a remarkable heart repair capacity after injury, and promises novel translational applications. Amputation and cryoinjury models are key research tools for
Ibberson, M., Nepomuceno-Chamorro, Isabel A, Benites da Costa, Ricardo M., González-Rosa, Juan Manuel, Ricardo M da Costa, Nazarov, Petr V., Isabel A Nepomuceno-Chamorro, Mark Ibberson, Mercader, N., da Costa, Ricardo M. Benites, Rodius, S., Rodius, Sophie, Nazarov, P.V., González Rosa, Juan Manuel, Azuaje, F., Xenarios, I., Ibberson, Mark, Juan González-Rosa, Sophie Rodius, da Costa, Ricardo M Benites, Mercader Huber, Nadia, Francisco Azuaje, Jeanty, C., Ioannis Xenarios, Jeanty, Céline, Céline Jeanty, Nepomuceno Chamorro, Isabel de los Ángeles, Azuaje, Francisco, Petr V Nazarov, da Costa, R.M., Mercader, Nadia, Xenarios, Ioannis, Nadia Mercader, Nepomuceno-Chamorro, I.A., González-Rosa, J.M., Nepomuceno-Chamorro, Isabel A., Nazarov, Petr V   +36 more
core   +1 more source

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Molecular Therapy: Methods & Clinical Development, 2020
Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of ...
Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard, Mati Lopez-Grancha, Nathalie Schussler, Anke Steinmetz, Jochen Beninga, Denis Boulay, Philippe Dugay, Patrick Verdier, Nadine Aubin, Gihad Dargazanli, Catarina Chaves, Elisabeth Genet, Yves Lossouarn, Christophe Loux, François Michoux, Nicolas Moindrot, Franck Chanut, Thierry Gury, Stéphanie Eyquem, Delphine Valente, Olivier Bergis, Ercole Rao, Dominique Lesuisse   +25 more
doaj   +1 more source

Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig

Antioxidants, 2021
Oxidative stress is directly linked to non-alcoholic fatty liver disease (NAFLD) and the progression to steaotohepatitis (NASH). Thus, a beneficial role of antioxidants in delaying disease progression and/or accelerating recovery may be expected, as ...
Josephine Skat-Rørdam, Kamilla Pedersen, Gry Freja Skovsted, Ida Gregersen, Sara Vangsgaard, David H. Ipsen, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg   +8 more
doaj   +1 more source

Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D

Frontiers in Cellular and Infection Microbiology, 2022
Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second most common sexually transmitted infection worldwide. Disease progression, drug discovery, and basic host-pathogen interactions are studied using different approaches ...
Motaharehsadat Heydarian, Eva Rühl, Ravisha Rawal, Vera Kozjak-Pavlovic   +3 more
doaj   +1 more source

In vitro and in vivo models for monkeypox

iScience, 2023
The emergence and rapid spread outside of monkeypox virus (MPXV) to non-endemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV.
Rafael Borges Rosa, Emilene Ferreira de Castro, Murilo Vieira da Silva, Denise Caroline Paiva Ferreira, Ana Carolina Gomes Jardim, Igor Andrade Santos, Mikaela dos Santos Marinho, Flávia Batista Ferreira França, Lindomar José Pena   +8 more
openaire   +3 more sources

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%, emphasizing the need for novel effective therapeutics against PDAC.
Morton, J.P., Heinrich, Marcel A.; id_orcid, Mostafa, Ahmed M.R.H., Heinrich, M.A., Hawinkels, Lukas J.A.C., Morton, Jennifer P., Mostafa, A.M.R.H., Heinrich, Marcel A., Prakash, J., Prakash, Jai, Hawinkels, L.J.A.C.   +10 more
core   +2 more sources