Results 11 to 20 of about 1,311,826 (266)
In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus
International Journal of Molecular Sciences, 2022 Pemphigus is a life-threatening autoimmune disease. Several phenotypic variants are part of this family of bullous disorders. The disease is mainly mediated by pathogenic autoantibodies, but is also directed against two desmosomal adhesion proteins, desmoglein 1 (DSG1) and 3 (DSG3), which are expressed in the skin and mucosae.
Roberta Lotti +4 more
openaire +2 more sources
Modeling metastasis in vivo [PDF]
Carcinogenesis, 2004 Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis.
Chand, Khanna, Kent, Hunter
openaire +2 more sources
Alzheimer’s Research & Therapy, 2022 Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge +7 more
doaj +1 more source
mAbs, 2020 Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per ...
Delphine Valente +12 more
doaj +1 more source
In vivo cerebral aneurysm models [PDF]
Neurosurgical Focus, 2019 Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage and is associated with significant morbidity and death. Up to 50% of individuals do not survive aneurysm rupture, with the majority of survivors suffering some degree of neurological deficit.
John W, Thompson +9 more
openaire +2 more sources
Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
Communications Biology, 2021 Ku et al. report a lentiviral (LV) vector system in which expression of vaccine antigens is driven by β2-microglobulin (β2m) promoter. Conducting comparative studies in mice and rats, they find that LV-based vaccine outperforms the ‘gold-standard’ Ad5 by
Min Wen Ku +7 more
doaj +1 more source
In vivo models of angiogenesis [PDF]
Journal of Cellular and Molecular Medicine, 2006 The process of building new blood vessels (angiogenesis) and controlling the propagation of blood vessels (anti-angiogenesis) are fundamental to human health, as they play key roles in wound healing and tissue growth. More than 500 million people may stand to benefit from anti- or pro-angiogenic treatments in the coming decades [National Cancer ...
openaire +2 more sources
Emerging cancer models for drugs and novel dosages development [PDF]
World Cancer Research Journal, 2022 Objective: Cancer is the primary cause of death all over the world, despite of its early detection and novel therapies available. The process of cancer drug development is growing tremendously.
P. Das, M. Das
doaj +1 more source
In vitro and in vivo models for monkeypox
iScience, 2023 The emergence and rapid spread outside of monkeypox virus (MPXV) to non-endemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV.
Rafael Borges Rosa +8 more
openaire +3 more sources
Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
BMC Ophthalmology, 2023 Diabetic retinopathy (DR), one of the leading causes of visual impairment and blindness worldwide, is one of the major microvascular complications in diabetes mellitus (DM). Globally, DR prevalence among DM patients is 25%, and 6% have vision-threatening
Muhammad Zulfiqah Sadikan +9 more
doaj +1 more source