Results 11 to 20 of about 1,294,116 (267)
In vitro Modeling of Embryonal Tumors [PDF]
Frontiers in Cell and Developmental Biology, 2021 A subset of pediatric tumors affects very young children and are thought to arise during fetal life. A common theme is that these embryonal tumors hijack developmental programs, causing a block in differentiation and, as a consequence, unrestricted proliferation.
Lars Custers +5 more
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In Vitro Models for Neurogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The process of generating new neurons of different phenotype and function from undifferentiated stem and progenitor cells starts at very early stages of development and continues in discrete regions of the mammalian nervous system throughout life. Understanding mechanisms underlying neuronal cell development, biology, function, and interaction with ...
Hassan, Azari, Brent A, Reynolds
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In vitro Models of Neurodegenerative Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neurodegenerative diseases are progressive degenerative conditions characterized by the functional deterioration and ultimate loss of neurons. These incurable and debilitating diseases affect millions of people worldwide, and therefore represent a major global health challenge with severe implications for individuals and society.
Anna Slanzi +5 more
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Models of in vitro spermatogenesis [PDF]
Spermatogenesis, 2012 Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation process is more or less completely dependent upon the cells being located within the ...
Hunter, D. +3 more
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Progress in melanoma modelling in vitro [PDF]
Experimental Dermatology, 2018 AbstractMelanoma is one of the most studied neoplasia, although laboratory techniques used for investigating this tumor are not fully reliable. Animal models may not predict the human response due to differences in skin physiology and immunity. In addition, international guidelines recommend to develop processes that contribute to the reduction ...
Marconi, Alessandra +3 more
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Modeling the Leukemia Microenviroment In Vitro [PDF]
Frontiers in Oncology, 2020 Over the last decade, the active role of the microenvironment in the pathogenesis, development and drug resistance of B cell malignancies has been clearly established. It is known that the tissue microenvironment promotes proliferation and drug resistance of leukemic cells suggesting that successful treatments of B cell malignancies must target the ...
Cristina Scielzo +3 more
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In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview
Frontiers in Oncology, 2021 After leukemia, tumors of the brain and spine are the second most common form of cancer in children. Despite advances in treatment, brain tumors remain a leading cause of death in pediatric cancer patients and survivors often suffer from life-long ...
Zhiqin Li, Sigrid A. Langhans
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Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases
Pharmaceutics, 2023 Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative perturbations in the intracellular microenvironment constitutively controlled by glutathione peroxidase 4 (GPX4).
Inês Costa +6 more
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In vitro models of axon regeneration [PDF]
Experimental Neurology, 2017 A variety of in vitro models have been developed to understand the mechanisms underlying the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical development of regeneration-promoting therapeutics. These range from single-cell based assays that typically focus on molecular mechanisms to organotypic assays that aim to ...
Hassan, Al-Ali +3 more
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Frontiers in Veterinary Science, 2021 Neospora caninum and Toxoplasma gondii are one of the main concerns of the livestock sector as they cause important economic losses in ruminants due to the reproductive failure.
Iván Pastor-Fernández +4 more
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