Results 11 to 20 of about 1,346,069 (268)
Models of in vitro spermatogenesis [PDF]
Spermatogenesis, 2012 Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation process is more or less completely dependent upon the cells being located within the ...
Hunter, D. +3 more
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In Vitro Models for Neurogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The process of generating new neurons of different phenotype and function from undifferentiated stem and progenitor cells starts at very early stages of development and continues in discrete regions of the mammalian nervous system throughout life. Understanding mechanisms underlying neuronal cell development, biology, function, and interaction with ...
Hassan, Azari, Brent A, Reynolds
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In vitro Models of Neurodegenerative Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neurodegenerative diseases are progressive degenerative conditions characterized by the functional deterioration and ultimate loss of neurons. These incurable and debilitating diseases affect millions of people worldwide, and therefore represent a major global health challenge with severe implications for individuals and society.
Anna Slanzi +5 more
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Progress in melanoma modelling in vitro [PDF]
Experimental Dermatology, 2018 AbstractMelanoma is one of the most studied neoplasia, although laboratory techniques used for investigating this tumor are not fully reliable. Animal models may not predict the human response due to differences in skin physiology and immunity. In addition, international guidelines recommend to develop processes that contribute to the reduction ...
Marconi, Alessandra +3 more
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Frontiers in Veterinary Science, 2021 Neospora caninum and Toxoplasma gondii are one of the main concerns of the livestock sector as they cause important economic losses in ruminants due to the reproductive failure.
Iván Pastor-Fernández +4 more
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In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia
Biomolecules, 2020 Schizophrenia (SZ) is a complex psychiatric disorder characterized by positive, negative, and cognitive symptoms, and is not satisfactorily treated by current antipsychotics.
Oliwia Koszła +3 more
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Nanomaterials, 2022 The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized.
Valérie Forest
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Stem Cells, 2012 Abstract The current resurgence of interest in the cancer stem cell (CSC) hypothesis as possibly providing a unifying theory of cancer biology is fueled by the growing body of work on normal adult tissue stem cells and the promise that CSC may hold the key to one of the central problems of clinical oncology: tumor recurrence.
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In Vitro Models to Study Hepatotoxicity [PDF]
Toxicologic Pathology, 2002 Drug discovery and development consists of a series of processes starting with the demonstration of pharmacologica l effects in experimental cell and animal models and ending with drug safety and effi cacy studies in patients. A main limitation is often the unacceptabl e level of toxicity with the liver as the primary target organ.
David A, Groneberg +2 more
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Modeling the Leukemia Microenviroment In Vitro [PDF]
Frontiers in Oncology, 2020 Over the last decade, the active role of the microenvironment in the pathogenesis, development and drug resistance of B cell malignancies has been clearly established. It is known that the tissue microenvironment promotes proliferation and drug resistance of leukemic cells suggesting that successful treatments of B cell malignancies must target the ...
Cristina Scielzo +3 more
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