Results 121 to 130 of about 348,397 (157)
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In Vitro Reconstruction of Brain Tumor Microenvironment
Biochip Journal, 2019The cancer cells in brain tumors interact with their microenvironment, which includes stromal cells, the extracellular matrix (ECM), and the physical properties of tissues. The reciprocal interaction between cancer cells and the surrounding microenvironment regulates the biological behavior of cancer cells.
Ilkyoo Koh, Pilnam Kim, Kim Pilnam
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Modeling the profibrotic microenvironment in vitro : model validation
Biochemical and Biophysical Research Communications, 2023Establishing the molecular and cellular mechanisms of fibrosis requires the development of validated and reproducible models. The complexity of in vivo models challenges the monitoring of an individual cell fate, in some cases making it impossible. However, the set of factors affecting cells in
Olga Grigorieva +7 more
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Study of haemopoietic microenvironment in vitro
Nature, 1976THE concept of the haemopoietic inductive microenvironment as first proposed by Curry and Trentin1 has been amply confirmed by experiment. One salient feature of this concept relates to the role of the mouse spleen in promoting erythropoiesis rather than granulopoiesis. For example, in the clonal growth of transplanted bone marrow cells, the spleens of
G E, Van Zant, E, Goldwasser, J M, Baron
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The Applications and Challenges of the Development of In Vitro Tumor Microenvironment Chips
Cellular and Molecular Bioengineering, 2022The tumor microenvironment (TME) plays a critical, yet mechanistically elusive role in tumor development and progression, as well as drug resistance. To better understand the pathophysiology of the complex TME, a reductionist approach has been employed to create in vitro microfluidic models called "tumor chips".
Annika Johnson +6 more
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Engineering mammary tissue microenvironments in vitro
2022Breast cancer is the most common cancer in women worldwide, and while screening, diagnostic tools and treatments have improved over the decades, many women still succumb to the disease. The heterogeneity of breast cancer and the many subtypes and sites of origin mean that it is remains a difficult disease to fully elucidate.
Clegg, Julien +4 more
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Studies on the In Vitro Microenvironment in Man
1983In a preliminary manner, the data presented here characterize some features of MSC and their progenitors. The progenitors, at least in chronic myelogenous leukemia, are derived from the neoplastic pluripotent stem cell that also differentiates along lymphoid and myeloid pathways.
J W, Singer, A, Keating
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Epidermal barrier reaction to an in vitro psoriatic microenvironment
Experimental Cell Research, 2017Keratinocytes (KCs) and Langerhans cells (LCs) contribute to create the epidermal barrier. To form a functional epidermis, KCs express filaggrin and Toll-like Receptors (TLRs). LCs are the first line of epidermal defence and can be activated by interleukin (IL)-17 and Tumor Necrosis Factor (TNF)-alpha.
Donetti E. +8 more
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Studies of the Erythroid Inductive Microenvironment in Vitro
1977Hemopoietic inductive microenvironments, associated with the stroma of blood-forming tissues, demonstrate specificity in regulating blood cell formation (7, 8, 25). The inductive influences of microenvironments are radio-resistant, and their distribution can be mapped in radiated mice or rats injected with pluripotent stem cells (14).
Gary van Zant +2 more
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The influence of microenvironment on the cytotoxicity of TNF ∞ in vitro
International Journal of Radiation Oncology*Biology*Physics, 1994Abstract Purpose: Investigations were undertaken to study the influence of oxygen levels on tumor necrosis factor ∞ (TNF∞) toxicity in vitro . Methods and Materials: The cell line used to assess the cytotoxicity of TNF∞ was the mouse fibroblast line L929.
Louise E. Sampson, David J. Chaplin
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Characterization of the in vitro stromal microenvironment of human bone marrow
The International Journal of Cell Cloning, 1986Utilizing long-term in vitro culture techniques, we characterized the cellular composition and functional attributes of the human in vitro bone marrow stromal microenvironment. Morphologic, specific cytochemical and immunologic methods demonstrated that the marrow stromal adherent layer (AL) reached confluency at two to three weeks, and was comprised ...
E S, Strobel, R E, Gay, P L, Greenberg
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