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Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorates Testicular injury to improve spermatogenic disorder through PRDX1/TRAF6/TGFβ signaling pathway. [PDF]
Tian Y +6 more
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Restoration of fertility by in-vitro spermatogenesis
Lancet, The, 1999Carmen Mendoza +2 more
exaly +3 more sources
In vitro spermatogenesis [PDF]
The generation of functional sperm in vitro has been a goal for almost a century. Until recently, researchers have only succeeded in reproducing the early steps of spermatogenesis. This is not surprising given that spermatogenesis is a complicated process that requires the coordinated efforts of germ cells and several somatic cells within the tubular ...
Miles Wilkinson, Hye-Won Song
exaly +3 more sources
Prospects for spermatogenesis in vitro
Theriogenology, 2003In recent years, extraordinary progress has been made in a broad range of reproductive technologies, including spermatogonial transplantation in the male. However, effective procedures for the complete recapitulation of spermatogenesis in vitro, including meiosis, have remained elusive.
J E, Parks +3 more
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In vitro spermatogenesis: Why meiotic checkpoints matter
2023Successful in vitro spermatogenesis would generate functional haploid spermatids, and thus, form the basis for novel approaches to treat patients with impaired spermatogenesis or develop alternative strategies for male fertility preservation. Several culture strategies, including cell cultures using various stem cells and ex vivo cultures of testicular
Lei, Qijing +2 more
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Advances in human In vitro spermatogenesis: A review
Recent advances surrounding in vitro spermatogenesis (IVS) have shown potential in creating a new paradigm of regenerative medicine in the future of fertility treatments for males experiencing non-obstructive azoospermia (NOA). Male infertility is a common condition affecting approximately 15% of couples, with azoospermia being present in 15% of ...
Ryan Flannigan
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Spermatogenesis In Vitro: Searching for In Vivo Correlates
1987The development of methodology for the study of spermatogenesis in vitro has been a major task that remained elusive (Wolff and Haffen, 1965; Steinberger, 1975). Significant advances have been reported in the culture of meiotic cells of lilaceous plants (Hotta et al., 1966), and spermatogenic cells of Xenopus (Risley, 1983) and Drosophila (Liebrich ...
A L, Kierszenbaum +3 more
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SPERMATOGENESIS IN VITRO: COMPLETION OF MEIOSIS AND EARLY SPERMIOGENESIS
Endocrinology, 1983In vitro formation of haploid spermatids has not been convincingly demonstrated in mammals. To investigate this problem we selected defined segments of rat seminiferous tubules containing late pachytene and diakinetic primary spermatocytes (Stages XII and XIII of the cycle) for culture in a chemically defined medium.
M, Parvinen +5 more
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