Results 141 to 150 of about 114,054,514 (226)

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Humanin ameliorates diabetes‐induced testicular damage in a streptozotocin‐induced mouse model

Experimental Physiology, EarlyView.
Abstract Diabetes mellitus is a major metabolic disorder closely associated with oxidative stress and male reproductive dysfunction. Humanin, a mitochondria‐derived peptide, has been reported to exert cytoprotective, anti‐apoptotic and antioxidant effects in various disease models; however, its role in diabetes‐induced testicular damage remains unclear.
Munevver Gizem Hekim, Nalan Kaya Tektemur, Mete Ozcan   +2 more
wiley   +1 more source

Testosterone supports in vitro spermatogenesis in Leydig cell-deficient ΔFLE mouse testes

Leydig cells support spermatogenesis primarily through testosterone (T) production. However, whether T alone is sufficient remains unresolved. Here, using Leydig cell–deficient mice with deletion of a fetal Leydig enhancer (ΔFLE), we demonstrate that T ...
Kanako Miyabayashi, Miharu Yoshida, Kumiko Katagiri, Chihiro Hayashi, Shino Nagata, Yu Ishikawa-Yamauchi, Yuki Yamashita, Yuichi Shima, Miki Inoue, Takehiko Ogawa, Takuya Sato   +10 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

In-vitro spermatogenesis through testis modelling: Toward the generation of testicular organoids. [PDF]

Andrology, 2020
Richer G, Baert Y, Goossens E.
europepmc   +1 more source

Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Trazodone is an antidepressant approved for the treatment of major depressive disorder and is associated with a low incidence of sexual dysfunction. However, its effects on male reproductive health are not yet fully understood. Therefore, this study aimed to evaluate the effects of repeated trazodone administration on reproductive parameters ...
Maria Santana da Silva, Vitória Barros Marques, Fernanda Karoline Oliveira da Silva, Maele Oliveira de Sena, Yanka do Vale Carvalho, Bruna da Silva Figueiredo, Luana Talinne da Costa Gomes, Samia Ellen Alves Fernandes, Edherlayne Bezerra dos Santos Silva, Jackson Nazareno Gomes de Lima, Anna Karynna Alves de Alencar Rocha, Expedito Silva do Nascimento Junior, Elaine Cristina Gavioli, Edilson Dantas da Silva Junior   +13 more
wiley   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Editorial: Research advances in male fertility: New horizons for investigating human testicular function and development of clinical fertility preservation approaches

Frontiers in Endocrinology, 2022
Swati Sharma, Jan-Bernd Stukenborg, Stefan Schlatt   +2 more
doaj   +1 more source

Residence Near Agricultural Crops at Birth and Risk of Adult Testicular Germ Cell Tumors: A French Nationwide Case–Control Study Using Historical Aerial GIS Data

International Journal of Cancer, Volume 159, Issue 5, Page 1153-1166, 1 September 2026.
As the incidence of testicular germ cell tumors (TGCTs) rises, prenatal exposure to agricultural pesticides may represent an important risk factor. Here, geographic information system‐based measures of farmland proximity at birth were used as a proxy for early‐life pesticide exposure in France, a major pesticide consumer.
Aurélie M. N. Danjou, Astrid Coste, Lény Grassot, Elodie Faure, Carlos Crispim‐Junior, Laure Tougne Rodet, Olivia Pérol, Rémi Béranger, Jeanne Perrin, Barbara Charbotel, Joachim Schüz, Béatrice Fervers, the TESTIS study group, Helen Boyle, Aude Fléchon, Elodie Belladame, Véronique Drouineaud, Céline Chalas, Myriam Virlouvet, Lucile Ferreux, Guillemette Perier, Pauline Peretout, Diane Rivet, Sandrine Rulle, Florence Eustache, Nathalie Sermondade, Marine Durand, Rachel Levy, Isabelle Berthaut, Jacqueline Saias‐Magnan, Catherine Metzler‐Guillemain, Carole Daoud‐Deveze, Louis Bujan, Myriam Daudin, Florence Brugnon, Valérie Bruhat, Cyril Bouche, Isabelle Kocsinski, Marius Teletin, Françoise Schmitt, Nathalie Guyomard, Aline Papaxanthos, Volcy Soula, Sandrine Giscard d’Estaing, Pascale Dehee, Delphine Yalcinkaya, Céline Bouillon, Cynthia Frapsauce, Anne Viallon, Bérengère Ducrocq, Marie‐Ange Clarotti, Ethel Szerman, Amélie Ancelle, Oxana Blagosklonov, Séverine Bey, Célia Ravel, Ségolène Veau, Agnès Letremy, Patricia Fauque, Julie Barberet, Stéphanie Lattes, Emmanuelle Thibault, Catherine Diligent, Christel Hersant, Vanessa Loup‐Cabaniols, Anna Gala, Sylvianne Hennebicq, Julien Bessonnat, Marie‐Claude Blocquaux, Brigitte Dananché, Johan Spinosi, Matthieu Dubuis, Charlotte Carretero, Etienne Durand, Bénédicte Thomas, Rémi Ratajczak   +75 more
wiley   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, Volume 46, Issue 9, Page 3164-3176, September 2026.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source