Results 131 to 140 of about 114,054,514 (226)

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis

, 2011
The actin-based cytoskeleton plays a critical role in the seminiferous epithelium during spermatogenesis by conferring cell shape, adhesion, structural support and cell polarity to both Sertoli and developing germ cells, which are essential for ...
C. Yan Cheng, Will M. Lee, Michelle W.M. Li, Mruk, Dolores D., Lee, WWM, Lam, YL, Wing-Yee Lui, Cheng, CY, Lam, Yee-ling, Xiao, Xiang, Lui, Wing-Yee, Xiao, X, Dolores D. Mruk, Li, Michelle W.M., Silvestrini, B, Silvestrini, Bruno, Lee, Will M., Xiang Xiao, Lui, WY, Bonanomi, Michele, Bruno Silvestrini, Mruk, DD, Li, MWM, Cheng, C. Yan, Bonanomi, M, Michele Bonanomi, Yee-ling Lam   +26 more
core   +1 more source

Male Sexual and Reproductive Health in Diabetes and Obesity Pharmacotherapy: A Source‐Triangulated Counseling Map

Andrology, EarlyView.
ABSTRACT Background Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. Objectives The objective is to map these sources and define what each can support when counseling men receiving metabolic drugs ...
Marek Broul, Michal Dubský, Aneta Hujová, Michaela Liegertová   +3 more
wiley   +1 more source

Lactate‐Responsive Glycogen Dynamics Are Associated With Bull Sperm Motility and Fertilization Under Glucose‐Limited Conditions

Andrology, EarlyView.
ABSTRACT Background Mammalian sperm need to undergo hyperactivation, capacitation, and acrosome reaction to achieve fertilization competence. However, the female reproductive tract presents contrasting metabolic environments. The uterus is glucose‐rich, and the oviduct is lactate‐rich and glucose‐limited.
Md Faizul Hossain Miraz, Takahiro Yamanaka, Takashi Umehara, Shahrina Akter, Wambugu Enoc Njoroge, Masayuki Shimada   +5 more
wiley   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, EarlyView.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source

Mini Bioreactor Can Support In Vitro Spermatogenesis of Mouse Testicular Tissue. [PDF]

Cell J, 2022
Amirkhani Z, Movahedin M, Baheiraei N, Ghiaseddin A.   +3 more
europepmc   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, EarlyView.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Black Carp Mylopharyngodon piceus reproductive development and maturation in the Mississippi River basin

Journal of Fish Biology, EarlyView.
Abstract Black Carp Mylopharyngodon piceus are native to most major east Asian drainages and are internationally cultured for use as a food‐fish or a biological control for molluscs. We describe the reproductive biology of Black Carp from the growing invasive population in the Mississippi River basin through examination of incidental commercial ...
Patrick T. Kroboth, Anne M. Herndon, Cayla L. Carlson, Fred Williams III, Rachel N. Alvarez, Amy E. George   +5 more
wiley   +1 more source

Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Male preconception health remains a critically under‐addressed area of family planning. While research suggests air pollution may harm semen quality, downstream impacts on pregnancy, particularly for more vulnerable infertility treatment populations, are understudied.
Lindsey M. Russo, J. Richard Pilsner, Timothy P. Canty, Neil J. Perkins, Pauline Mendola, Karen C. Schliep, May Shaaban, Rachael B. Hemmert, Akanksha Singh, Allison M. Ring, James A. Vanderslice, C. Matthew Peterson, Erica B. Johnstone, Kaniz Rabeya, Carrie Nobles   +14 more
wiley   +1 more source