Results 131 to 140 of about 51,909 (235)

Some problems and errors in cytogenetic biodosimetry [PDF]

, 2016
Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2-3 standard deviations).
Kilchevsky, Alexander, Mosse, Irma, Nikolova, Nevena, Zhelev, Nikolai   +3 more
core   +5 more sources

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Intra-Testicular Signals Regulate Germ Cell Progression and Production of Qualitatively Mature Spermatozoa in Vertebrates [PDF]

, 2014
Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, FSH and LH, in response to stimulation exerted by Gonadotropin Releasing Hormone (
Gilda Cobellis, Riccardo Pierantoni, Rosanna Chianese, Rosaria Meccariello, Silvia Fasano, Teresa Chioccarelli, Vincenza Ciaramella   +6 more
core   +2 more sources

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Proteome of the testicular cell-conditioned medium supports germ cell differentiation in vitro

Journal of Advanced Veterinary and Animal Research
Objective: This study aimed to evaluate the effect of testicular cell conditioned medium (TCCM) on in vitro male germ cell differentiation and provide a proteomic profile of TCCM. Materials and Methods: TCCM was collected from 5-day-old mouse testicular
Wahono Esthi Prasetyaningtyas, Ni Wayan Kurniani Karja, Srihadi Agungpriyono, I Ketut Mudite Adnyane, Kusdiantoro Mohamad, Mokhamad Fahrudin   +5 more
doaj   +1 more source

Boosting Male Fertility: The Impact of Gonadotropin Therapy on Hypogonadotropic Hypogonadism—A Systematic Review and Meta‐Analysis

Andrology, EarlyView.
ABSTRACT Background Male hypogonadotropic hypogonadism typically presents with azoospermia and is one of the few causes of infertility amenable to a medical intervention. Gonadotropin therapy offers a chance to restore spermatogenesis and fertility in these individuals.
Manou Huijben, Anne Prinsen, Laetitia de Kort, Jetske van Breda   +3 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Technologized Reproduction in Space: A Space‐Bioethical Case for Assisted Procreation

Bioethics, EarlyView.
ABSTRACT With the increasing feasibility of space colonization, the issue of reproduction in space is becoming more relevant. As new settlements on the Moon, Mars, and other celestial bodies emerge, ensuring generational continuity will be essential for the survival and growth of these communities.
Maurizio Balistreri, Konrad Szocik
wiley   +1 more source

Spermatogonial Stem Cells and In Vitro Spermatogenesis: How Far Are We from a Human Testis on a Chip? [PDF]

Eur Urol Focus, 2023
Ramsoomair CK, Alver CG, Flannigan R, Ramasamy R, Agarwal A.   +4 more
europepmc   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source