Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Are activated B cells involved in the process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment [PDF]
, 2020 Fanrui Mo +5 more
openalex +1 more source
Self -Assembled Raccoon Dog Parvovirus VP2 Protein Confers Immunity Against RDPV Disease in Raccoon Dogs: In Vitro and in Vivo Studies [PDF]
, 2021 Linya Xia +6 more
openalex +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency [PDF]
, 2008 Yoshifumi Takei +9 more
openalex +1 more source
Thermal constraints on in vivo optogenetic manipulations. [PDF]
, 2019 A key assumption of optogenetics is that light only affects opsin-expressing neurons. However, illumination invariably heats tissue, and many physiological processes are temperature-sensitive.
Kreitzer, Anatol C +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
In vitro and in vivo drug disposition of cilengitide in animals and human [PDF]
, 2016 Hugues Dolgos +7 more
openalex +1 more source
Structure elucidation, biosynthesis, total synthesis and antibacterial in-vivo efficacy of myxobacterial Corramycin [PDF]
, 2022 Cédric Couturier +32 more
openalex +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source