Results 61 to 70 of about 5,806,183 (351)

Uji Aktivitas Antimalaria In Vivo dari Beberapa Fraksi Ekstrak Kulit Buah Manggis (Garcinia Manggostana Linn) pada Mencit (Mus Musculus ) yang Diinfeksi dengan Plasmodium Berghei [PDF]

, 2013
Malaria disease is still one public health problem in the world and affect the infant mortality rate, under five and pregnant women. The purpose of this study was to recognize in vivo antimalarial activity from hexane fraction, ethyl acetate, and ...
Aamruna, Y. (Yaum), Effendi, Z. (Zulham), Iqbal, M. (Muhammad), Suryawati, S. (Suryawati)   +3 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Homeostatic sleep regulation in the absence of the circadian sleep‐regulating component: effect of short light–dark cycles on sleep–wake stages and slow waves

BMC Neuroscience, 2021
Background Aside from the homeostatic and circadian components, light has itself an important, direct as well as indirect role in sleep regulation. Light exerts indirect sleep effect by modulating the circadian rhythms. Exposure to short light-dark cycle
Örs Szalontai, Attila Tóth, Máté Pethő, Dóra Keserű, Tünde Hajnik, László Détári   +5 more
doaj   +1 more source

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

Biomedicines, 2023
Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Gülşah Okutan, Eva Ruiz Casares, Teresa Perucho Alcalde, Guerthy Melissa Sánchez Niño, Bruno F. Penadés, Ana Terrén Lora, Lorena Torrente Estríngana, Sara López Oliva, Ismael San Mauro Martín   +8 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Human Neural Stem Cell Induced Functional Network Stabilization After Cortical Stroke: A Longitudinal Resting-State fMRI Study in Mice

Frontiers in Cellular Neuroscience, 2020
Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes.
Anuka Minassian, Claudia Green, Michael Diedenhofen, Stefanie Vogel, Simon Hess, Simon Hess, Maren Stoeber, Marina Dobrivojevic Radmilovic, Marina Dobrivojevic Radmilovic, Dirk Wiedermann, Peter Kloppenburg, Peter Kloppenburg, Mathias Hoehn, Mathias Hoehn   +13 more
doaj   +1 more source

Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination

, 2018
Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique
Darvin, Maxim E., Gersonde, Ingo, Moralejo, Benito, Roth, Martin M., Schleusener, Johannes, Schmälzlin, Elmar, Thiede, Gisela   +6 more
core   +1 more source

A robust protocol for in vivo THz skin measurements [PDF]

, 2019
This work presents an experimental setup to control the way in which pressure interferes with the repeatability of in vivo THz skin measurements. By integrating a pressure sensor circuit into our THz system, it is possible to identify which measurements ...
Blasco, Laurent, Cebrian, Juan, Hernandez-Serrano, A. I, Lindley-Hatcher, Hannah, Pickwell-MacPherson, Emma, Sun, Qiushuo, Wang, Jiarui   +6 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source