Results 61 to 70 of about 3,388,289 (318)

An update on mycobacteria and the development of allergic diseases

, 2015
Mycobacteria can diminish allergic and asthmatic manifestations. This means that mycobacteria could offer therapeutical opportunities as an 'anti-allergic' vaccine.In humans, the genetic background and the environment probably contribute to the ...
Sub Airway in vivo Pharmacology, Folkerts, G., Pharmacology, G Folkerts   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

vivo-project/VIVO: Release vivo-1.14.1

<p><strong>Release vivo 1.14.1</strong><br/>It is recommended that you review the 1.14 Documentation and the VIVO/Vitro READMEs on github before you start.<br/>If you are new to VIVO/Vitro it is suggested that you take ...
Jim Blake, Stefan-Wolff, Brian Caruso, Andrew Woods, Nate Prewitt, William Welling, Don Elsborg, hudajkhan, Ralph O'Flinn, Georgy Litvinov, Alex Viggio, tworrall, Ben, Ted Lawless, Miloš Popović, Arfon Smith, vivo-uab, Jon Corson-Rikert, Steve McKay, Mike Conlon, Dragan Ivanovic, hauschke, Brian Lowe, Stephen V. Williams, Holly Mistlebauer, Michel Héon, Laura Wrubel, Graham Triggs   +27 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors

Neoplasia: An International Journal for Oncology Research, 2017
Improving the congruity of preclinical models with cancer as it is manifested in humans is a potential way to mitigate the high attrition rate of new cancer therapies in the clinic.
Erwin R. Boghaert, Xin Lu, Paul E. Hessler, Thomas P. McGonigal, Anatol Oleksijew, Michael J. Mitten, Kelly Foster-Duke, Jonathan A. Hickson, Vitor E. Santo, Catarina Brito, Tamar Uziel, Kedar S. Vaidya   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

vivo-project/VIVO: Release vivo-1.14.2

<p><strong>Release vivo 1.14.2</strong><br/>It is recommended that you review the 1.14 Documentation and the VIVO/Vitro READMEs on github before you start.<br/>If you are new to VIVO/Vitro it is suggested that you take ...
Jim Blake, Stefan-Wolff, Brian Caruso, Andrew Woods, Nate Prewitt, William Welling, Don Elsborg, hudajkhan, Ralph O'Flinn, Christian Hauschke, Georgy Litvinov, Alex Viggio, tworrall, Ben, Ted Lawless, Miloš Popović, Arfon Smith, vivo-uab, Jon Corson-Rikert, Steve McKay, Mike Conlon, Dragan Ivanovic, Brian Lowe, Stephen V. Williams, Holly Mistlebauer, Michel Héon, Laura Wrubel, Graham Triggs   +27 more
core   +1 more source

Varianti ed errori nella traduzione anglosassone dei "Dialogi" di Gregorio Magno

, 2021
The Old English translation of Gregory's Dialogues appears to be relying on a distinctive tradition of the Latin text which differed in many respects from the Continental tradition.
Franco De Vivo
core  

Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

EJNMMI Research, 2018
Background Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer.
Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, Martin Bauer, Oliver Langer, Sylvain Auvity, Nicolas Tournier   +7 more
doaj   +1 more source