Results 91 to 100 of about 115,798,289 (300)

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Rush, Catherine, Jenkinson, E.J., Bryson, Karen, Rush, C.M., Rush, Catherine M., Gibson, VB, Gibson VB, White, Andrea, Brewer JM, Jenkinson EJ, Bryson, Karen J., Jenkinson, Eric J., White, Andrea J., Grassia, Gianlucca, Grassia, G, Rush, CM, Garside, P, Maffia, Pasquale, Benson, Robert, Bryson KJ, Benson, RA, Benson, R.A., Jenkinson, Eric, Maffia, P., Anderson, Graham, Garside P., Grassia, G., McInnes, Iain, Gibson, V.B., Benson, Robert A., McInnes, Iain B., Gibson, Vivienne, White, A.J., Benson RA, Jenkins, E, McInnes, I.B., Bryson, K.J., Anderson, G., White, A, Brewer, James M., McInnes, IB, White AJ, Brewer, J.M., Gibson, Vivienne B., McInnes IB, Bryson, KJ, Grassia, Gianluca, Brewer, James, Maffia, P, Rush CM, Garside, P., Anderson G, Garside, Paul, Brewer, JM   +53 more
core   +1 more source

Aging Reduces the Functional Brain Networks Strength—a Resting State fMRI Study of Healthy Mouse Brain

Frontiers in Aging Neuroscience, 2019
Resting-state functional magnetic resonance imaging (rsfMRI) is increasingly used to unravel the functional neuronal networks in health and disease.
Ander Egimendia, Ander Egimendia, Anuka Minassian, Michael Diedenhofen, Dirk Wiedermann, Pedro Ramos-Cabrer, Pedro Ramos-Cabrer, Mathias Hoehn   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles [PDF]

, 2017
Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have great potential in nanotheranostic applications. Here, we report the first successful pretargeted
Windhorst, Albert D., Roivainen, Anne, Outi Keinänen, Liljenbäck, Heidi, Helena Virtanen, Salonen, Jarno J., Ermei M. Mäkilä, Rici Lindgren, Oikonen, Vesa, Sarparanta, Mirkka, Lindgren, Rici, Anne Roivainen, Molthoff, Carla, Heidi Liljenbäck, Albert D. Windhorst, Jarno J. Salonen, Anu J. Airaksinen, Airaksinen, Anu J., Virtanen, Helena, Mirkka Sarparanta, Vesa Oikonen, Keinänen, Outi, Mäkilä, Ermei M., Carla Molthoff   +23 more
core   +1 more source

VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models

Neoplasia: An International Journal for Oncology Research, 2019
Cancer immunotherapies have demonstrated durable responses in a range of different cancers. However, only a subset of patients responds to these therapies.
Johannes Riegler, Herman Gill, Annie Ogasawara, Maj Hedehus, Vincent Javinal, Jason Oeh, Gregory Z. Ferl, Jan Marik, Simon Williams, Deepak Sampath, Jill Schartner, Richard A.D. Carano   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Brain Tissue Conductivity Measurements with MR-Electrical Properties Tomography: An In Vivo Study [PDF]

, 2021
First in vivo brain conductivity reconstructions using Helmholtz MR-Electrical Properties Tomography (MR-EPT) have been published. However, a large variation in the reconstructed conductivity values is reported and these values differ from ex vivo ...
Vink, Jord J T, Mandija, Stefano, van den Berg, Cornelis A T, Neggers, Sebastian F W, Petrov, Petar I   +4 more
core  

Protocol for in vivo fluorescence lifetime microendoscopic imaging of the murine femoral marrow

Methods in Microscopy
We present a protocol for micro-endoscopic fluorescence lifetime imaging in the femoral marrow of mice allowing the analysis of NAD(P)H-dependent metabolism at single cell level, in vivo.
Fiedler Alexander F., Niesner Raluca A.
doaj   +1 more source

Noninvasive MRI of Endothelial Cell Response to Human Breast Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2006
We have developed a noninvasive magnetic resonance imaging (MRI) assay to characterize human umbilical vein endothelial cell (HUVEC) motility, invasion, and network formation in response to the presence of cancer cells.
Barjor Gimi, Noriko Mori, Ellen Ackerstaff, Emma E. Frost, Jeff W.M. Bulte, Zaver M. Bhujwalla   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source