Results 81 to 90 of about 115,798,289 (300)
Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]
, 2012 <b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D. +19 more
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Preclinical molecular imaging: from the laboratory bench to the patient.
, 2015 Preclinical molecular imaging plays a key role in the study of diseases and the development – evaluation - validation of novel treatments and diagnostic techniques.
Plenevaux, Alain
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models
Neoplasia: An International Journal for Oncology Research, 2012 Tumor hypoxia triggers signaling cascades that significantly affect biologic outcomes such as resistance to radiotherapy and chemotherapy in breast cancer. Hypoxic regions in solid tumor are spatially heterogeneous.
Lu Jiang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Frontiers in Immunology, 2019 Microglia are the brain-innate immune cells which actively surveil their environment and mediate multiple aspects of neuroinflammation, due to their ability to acquire diverse activation states and phenotypes. Simplified, M1-like microglia are defined as
Franziska M. Collmann +10 more
doaj +1 more source
Validation of an Automatic Arousal Detection Algorithm for Whole-Night Sleep EEG Recordings
Clocks & Sleep, 2020 Arousals during sleep are transient accelerations of the EEG signal, considered to reflect sleep perturbations associated with poorer sleep quality. They are typically detected by visual inspection, which is time consuming, subjective, and prevents good ...
Daphne Chylinski +12 more
doaj +1 more source
In vivo imaging of zebrafish embryogenesis [PDF]
Methods, 2013 The zebrafish Danio rerio has emerged as a powerful vertebrate model system that lends itself particularly well to quantitative investigations with live imaging approaches, owing to its exceptionally high optical clarity in embryonic and larval stages.
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Multimodality Imaging of Tumour Pathophysiology and Response to Pharmacological Intervention [PDF]
, 2015 This thesis describes the need for imaging the tumour pathophysiological microenvironment in order to understand response to treatment. Specifically looking at tumour vascularisation in in vivo murine xenograft models of disease, response to treatment ...
Johnson, SP
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