Results 51 to 60 of about 115,798,289 (300)

Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models

Frontiers in Medicine, 2023
BackgroundClinical attempts to find benefit from specifically targeting and boosting resistant hypoxic tumor subvolumes have been promising but inconclusive.
Inna Gertsenshteyn, Inna Gertsenshteyn, Inna Gertsenshteyn, Boris Epel, Boris Epel, Boris Epel, Mihai Giurcanu, Eugene Barth, Eugene Barth, John Lukens, John Lukens, Kayla Hall, Kayla Hall, Jenipher Flores Martinez, Jenipher Flores Martinez, Mellissa Grana, Mellissa Grana, Matthew Maggio, Matthew Maggio, Richard C. Miller, Richard C. Miller, Subramanian V. Sundramoorthy, Subramanian V. Sundramoorthy, Martyna Krzykawska-Serda, Martyna Krzykawska-Serda, Erik Pearson, Erik Pearson, Bulent Aydogan, Ralph R. Weichselbaum, Victor M. Tormyshev, Mrignayani Kotecha, Howard J. Halpern, Howard J. Halpern   +32 more
doaj   +1 more source

In Vivo Imaging of Human Neuroinflammation [PDF]

ACS Chemical Neuroscience, 2016
Neuroinflammation is implicated in the pathophysiology of a growing number of human disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic lateral sclerosis. As a result, interest in the development of novel methods to investigate neuroinflammatory processes, for the purpose of diagnosis, development of new ...
Albrecht DS, Granziera C, Hooker JM, Loggia ML   +3 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microstructural parameter estimation in vivo using diffusion MRI and structured prior information. [PDF]

, 2016
Diffusion MRI has recently been used with detailed models to probe tissue microstructure. Much of this work has been performed ex vivo with powerful scanner hardware, to gain sensitivity to parameters such as axon radius.
Weiskopf, N, Weiskopf, N. ; https://orcid.org/, Zoltan Nagy, Chris A. Clark, Clark, CA, Clayden, JD, Alexander, DC, Nikolaus Weiskopf, Nagy, Z, Alexander, D., Nagy, Z., Clark, C., Jonathan D. Clayden, Daniel C. Alexander, Clayden, J.   +14 more
core   +1 more source

Resolution and b value dependent structural connectome in ex vivo mouse brain

NeuroImage, 2022
Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and
Stephanie Crater, Surendra Maharjan, Yi Qi, Qi Zhao, Gary Cofer, James C. Cook, G. Allan Johnson, Nian Wang   +7 more
doaj   +1 more source

In Vivo Human Amyloid Imaging [PDF]

Current Alzheimer Research, 2011
PET imaging agents such as Pittsburgh compound B (PiB) allow detection of fibrillar β-amyloid (Aβ) in vivo. In addition to quantification of Aβ deposition in mild cognitive impairment and Alzheimer's disease, PiB has also increased our understanding of Aβ deposition in older adults without cognitive impairment. In vivo Aβ deposition has been studied in
J, Sojkova, S M, Resnick
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A new theory of tree sap flow [PDF]

PeerJ
Introduction The theory of water transport in trees, according to which the main driving force of water movement is the suction created by the evaporation of water by the meniscus (the curved surface of the capillary liquid column) on the evaporating ...
András Török, Anikó Anna Hajduné Kubovje, Balázs Hardi, Ralf Bergmann, Krisztián Szigeti, Domokos Máthé, Imre Hegedüs   +6 more
doaj   +2 more sources

In vivo imaging of neural activity [PDF]

Nature Methods, 2017
Since the introduction of calcium imaging to monitor neuronal activity with single-cell resolution, optical imaging methods have revolutionized neuroscience by enabling systematic recordings of neuronal circuits in living animals. The plethora of methods for functional neural imaging can be daunting to the nonexpert to navigate. Here we review advanced
Weijian Yang, Rafael Yuste
openaire   +4 more sources