Results 91 to 100 of about 681,576 (264)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modulation and Protection Effects of Antioxidant Compounds against Oxidant Induced Developmental Toxicity in Zebrafish

Antioxidants, 2020
The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict in vivo protective activity or to determine their underlying mechanisms of action.
Nuria Boix, Elisabet Teixido, Ester Pique, Juan Maria Llobet, Jesus Gomez-Catalan   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Vitamin D3 contribution to systemic and local control of Salmonella Typhimurium infection in an in vivo mouse model

Frontiers in Molecular Biosciences
IntroductionVitamin D serves as a critical modulator of innate and adaptive immune responses. Its active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), exhibits potent antimicrobial activity in both humans and mice, positioning it as a promising ...
Michela Tarantino, Dorotea Ippolito, Giorgia Barbieri, Paola Petrucci, Alessia Tammaro, Roberta Tassinari, Francesca Maranghi, Emma Michetti, Serena Ammendola, Massimiliano Francia, Rosanna Adone, Paolo Pasquali, Barbara Chirullo   +12 more
doaj   +1 more source

The 3’UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish

Frontiers in Molecular Neuroscience, 2018
Formation of functional myelin sheaths within the central nervous system depends on expression of myelin basic protein (MBP). Following process extension and wrapping around axonal segments, this highly basic protein is required for compaction of the ...
Julie Torvund-Jensen, Jes Steengaard, Liselotte B. Askebjerg, Kasper Kjaer-Sorensen, Lisbeth S. Laursen   +4 more
doaj   +1 more source

Development of a chimeric model to study and manipulate human microglia in vivo

Neuron, 2019
SUMMARY iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive to their environment, exhibiting transcriptomic deficiencies when kept in isolation ...
J. Hasselmann, M. Coburn, W. England, Dario X. Figueroa Velez, S. Shabestari, Christina Tu, Amanda McQuade, M. Kolahdouzan, Karla Echeverria, C. Claes, Taylor Nakayama, Ricardo Azevedo, N. Coufal, Claudia Z. Han, Brian J Cummings, H. Davtyan, C. Glass, Luke M. Healy, S. Gandhi, R. Spitale, Mathew Blurton-Jones   +20 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Histomorphometric Evaluation of Subchronic and Chronic Effects of Novel Experimental Calcium Aluminate- and Calcium Silicate-Based Dental Cement Materials on Rat Liver, Kidney, Brain, and Spleen Tissues

Journal of Functional Biomaterials
Although biocompatible calcium silicate cements (CSCs) and calcium aluminate cements (CACs) may induce local and systemic adverse effects. This study aimed to evaluate the subchronic and chronic effects of experimental CAC and CSC mixtures on rat liver ...
Veljko Ilić, Sanja Milutinović-Smiljanić, Vladimir Biočanin, Jovana Kuzmanović Pfićer, Tatjana Tasić, Vesna Danilović, Nina Japundžić-Žigon, Smiljana Paraš, Vukoman Jokanović, Dejan Ćetković, Đorđe Antonijević   +10 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source