Results 81 to 90 of about 1,733,123 (312)
, 2012 Effect of cerebral ischemia and postischemic recovery during aging on mitochondrial energy metabolism: an in vivo model for experimental ...
FERRARI, FEDERICA +3 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2020 [EN] Currently, Helicobacter pylori is the unique biological carcinogenic agent. The search for antimicrobial alternatives to antibiotics against this pathogen has been categorized as a priority due to the drastic failure associated with current ...
Siguemoto, Érica +7 more
core +1 more source
Antioxidants, 2020 The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict in vivo protective activity or to determine their underlying mechanisms of action.
Nuria Boix +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Antioxidant potentials of flaxseed by in vivo model
, 2006 The present study reports the antioxidant activity of flaxseed as measured by feeding weanling albino rats with 5.0% and 10.0% of flaxseed (constituting approximately 0.75 and 1.5 g kg(-1)) for 14 days followed by challenging animals with 2.0 g kg(-1) b ...
Murthy, K. N. C. +4 more
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Frontiers in Molecular BiosciencesIntroductionVitamin D serves as a critical modulator of innate and adaptive immune responses. Its active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), exhibits potent antimicrobial activity in both humans and mice, positioning it as a promising ...
Michela Tarantino +12 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Formation of functional myelin sheaths within the central nervous system depends on expression of myelin basic protein (MBP). Following process extension and wrapping around axonal segments, this highly basic protein is required for compaction of the ...
Julie Torvund-Jensen +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Graphite nanoplatelets and Caenorhabditis elegans: Insights from an in vivo model
, 2012 We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points.
BROGGI, ALESSANDRA +7 more
core +1 more source