Results 61 to 70 of about 681,576 (264)
Treatment of a Mouse Model of ALS by In Vivo Base Editing.
Molecular Therapy, 2020 Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (SOD1) gene. Although ALS is currently incurable, CRISPR base editors hold the potential to treat the disease through ...
C. K. Lim +8 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
In vivo wireless channel modeling [PDF]
, 2016 25 pages, 17 figures, 7 tables, URL of the final version: https://digital-library.theiet.org/content/books/10.1049/pbte065e_ch7 .
Demir, Ali Fatih +7 more
openaire +3 more sources
In vitro and in vivo model systems used in prostate cancer research
Journal of Biological Methods, 2015 New incidence of prostate cancer is a major public health issue in the Western world, and has been rising in other areas of the globe in recent years.
David M. Cunningham, Z. You
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Ruhuna Journal of ScienceFenugreek (Trigonella foenum-graecum) is well known worldwide as a spice and as an herbal remedy for combating high blood sugar. The present study investigated the effect of fenugreek on glycemic, lipidemic and immunomodulatory potential using Wistar ...
Piumi S. Samarakoon +3 more
doaj +1 more source
MODERN METHODS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY MODELING IN VIVO
Вопросы современной педиатрии, 2014 Review describes modern approaches to the study of pathogenic mechanisms of perinatal hypoxic-ischemic brain injury. The classification of modeling methods hypoxic-ischemic brain injury in vivo reflects the basic approaches to disease modeling. Given the
A. V. Morgun +5 more
doaj +1 more source
Advances in Renal Cell Carcinoma Drug Resistance Models
Frontiers in Oncology, 2022 Renal cell carcinoma (RCC) is the most common form of kidney cancer. Systemic therapy is the preferred method to eliminate residual cancer cells after surgery and prolong the survival of patients with inoperable RCC.
Yien Xiang +4 more
doaj +1 more source
Acta Neuropathologica, 2014 Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic neurodegenerative tauopathies.
Z. Ahmed +16 more
semanticscholar +1 more source