Results 51 to 60 of about 1,733,123 (312)

Development of experimental models of reactivated toxoplasmosis [PDF]

open access: yesMedicinski Podmladak
Toxoplasmosis is one of the most widespread zoonosis worldwide, since Toxoplasma gondii (T. gondii) is a ubiquitous obligate intracellular protozoan parasite that infects up to one third of the human population. Although infection is usually asymptomatic
Bauman Neda   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

In vivo wireless channel modeling [PDF]

open access: yes, 2016
25 pages, 17 figures, 7 tables, URL of the final version: https://digital-library.theiet.org/content/books/10.1049/pbte065e_ch7 .
Demir, Ali Fatih   +7 more
openaire   +3 more sources

A list of different in vitro and in vivo model systems used to study miR-34 functions.

open access: yes, 2013
A list of different in vitro and in vivo model systems used to study miR-34 functions.
Michelle Craig Barton (180715)   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles

open access: yes, 2006
Effective interstitial transport of particles is necessary for injected drug/diagnostic agents to reach the intended target; however, quantitative methods to estimate such transport parameters are lacking.
Swartz, M. A.   +3 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

MODERN METHODS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY MODELING IN VIVO

open access: yesВопросы современной педиатрии, 2014
Review describes modern approaches to the study of pathogenic mechanisms of perinatal hypoxic-ischemic brain injury. The classification of modeling methods hypoxic-ischemic brain injury in vivo reflects the basic approaches to disease modeling. Given the
A. V. Morgun   +5 more
doaj   +1 more source

Advances in Renal Cell Carcinoma Drug Resistance Models

open access: yesFrontiers in Oncology, 2022
Renal cell carcinoma (RCC) is the most common form of kidney cancer. Systemic therapy is the preferred method to eliminate residual cancer cells after surgery and prolong the survival of patients with inoperable RCC.
Yien Xiang   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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