Results 41 to 50 of about 1,790,703 (269)
Models for Studying Angiogenesis in Vivo
The International Journal of Biological Markers, 1999 In vivo and in vitro techniques are available for reseach on the functions of endothelial cells during angiogenesis. In this review we describe and evaluate the methodology and specific features of some of the most frequently used in vivo assays.
RIBATTI, Domenico, VACCA, Angelo
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Frontiers in Microbiology, 2020 The chemotherapeutic options for methicillin-resistant Staphylococcus aureus (MRSA) infections are limited. Due to the multiple resistant MRSA, therapeutic failure has occurred frequently, even using antibiotics belonging to different categories in ...
Yang Yu +11 more
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Tumor models in the investigation of oral cancer pathogenesis and treatment development
RUDN Journal of MedicineRelevance. Oral cancer is one of the most common cancers among neoplasms of the head and neck. Oral cancer is characterized by a poor prognosis, a lack of specific biomarkers and highly effective targeted treatment.
Maria S. Tretyakova +4 more
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Disease Models & Mechanisms, 2022 With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed.
Nils-Jørgen Knudsen Dal +9 more
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In Vivo Model of Small Intestine [PDF]
, 2017 The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases.
Maxime M, Mahe +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Modeling protein folding in vivo [PDF]
Biology Direct, 2018 A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways.
Irina Sorokina, Arcady Mushegian
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A Model for the Action of Vinblastine in Vivo
Biophysical Journal, 1966 A model for the action of vinblastine (VLB) on cells multiplying exponentially in vivo with a generation time, T(G), has been derived. It is based on the assumption that cells attempting to pass through mitosis in the presence of VLB lose their proliferative capacity and that this lethal effect occurs only when the cells are exposed to a concentration ...
Valeriote, F.A. +2 more
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