Results 41 to 50 of about 1,733,123 (312)
Modeling Melanoma In Vitro and In Vivo [PDF]
Healthcare, 2013 The behavior of melanoma cells has traditionally been studied in vitro in two-dimensional cell culture with cells adhering to plastic dishes. However, in order to mimic the three-dimensional architecture of a melanoma, as well as its interactions with the tumor microenvironment, there has been the need for more physiologically relevant models.
Beaumont, Kimberley A. +2 more
openaire +5 more sources
The stented anatomy of the in vivo model after 6-month implantation.
, 2014 The stented anatomy of the in vivo model after 6-month implantation.
Zhonghua Li (579177) +7 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Galleria mellonella as a Novel In Vivo Model to Screen Natural Product-Derived Modulators of Innate Immunity [PDF]
, 2022 Immunomodulators are drugs that either stimulate or suppress the immune system in response to an immunopathological disease or cancer. The majority of clinically approved immunomodulators are either chemically synthesised (e.g., dexamethasone) or protein-
Owen Kavanagh +3 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Modeling protein folding in vivo [PDF]
Biology Direct, 2018 A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways.
Irina Sorokina, Arcady Mushegian
openaire +3 more sources
, 2022 BackgroundNeuropathic pain is one of the most difficult to treat chronic pain syndromes. It has significant effects on patients’ quality of life and substantially adds to the burden of direct and indirect medical costs.
María Luisa González-Fernández (13758190) +5 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
, 2018 Supplemental material, DS_10.1177_0022034518789898 for Early Caries in an In Vivo Model: Structural and Nanomechanical Characterization by D.T. Yucesoy, H. Fong, C. Gresswell, S. Saadat, W.O. Chung, S. Dogan and M.
W.O. Chung (5585078) +6 more
core +1 more source
, 2022 BackgroundNeuropathic pain is one of the most difficult to treat chronic pain syndromes. It has significant effects on patients’ quality of life and substantially adds to the burden of direct and indirect medical costs.
María Luisa González-Fernández (13758190) +5 more
core +1 more source